The Impact of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Infants Treated with Photo-therapy: A Single-Blind Randomized Clinical Trial
- سال انتشار: 1403
- محل انتشار: مجله علمی ناباروری ایران، دوره: 15، شماره: 4
- کد COI اختصاصی: JR_IRJN-15-4_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 161
نویسندگان
Neonatal and Children’s Health Research Center, Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
Neonatal and Children’s Health Research Center , Golestan University of Medical Sciences, Gorgan, Iran
Neonatal and Children’s Health Research Center , Golestan University of Medical Sciences, Gorgan, Iran
Neonatal and Children and rsquo, Health Research Center, Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital Golestan University of Medical Sciences, Gorgan, Iran Golestan University of Medical Sciences, Gorgan, Iran
چکیده
Background: Infantile jaundice affects up to ۸۴% of term infants and is a primary cause of re-hospitalization. Phototherapy, the primary therapeutic intervention, may be associated with several complications. Therefore, employing additional compensatory therapies could reduce the duration of phototherapy and its adverse effects. Methods: A single-blind randomized clinical trial was conducted on newborns with indirect hyperbilirubinemia (IHB) undergoing phototherapy. Patients were randomly assigned to two groups: the intervention group received phototherapy and ۱۰mg/kg of Ursodeoxycholic acid, taken twice a day with water as the solvent, while the control group received phototherapy and a placebo (water). Total bilirubin levels were measured every ۱۲ hours, and the groups were compared regarding the reduction duration of bilirubin < ۱۰ mg/dl and the duration of phototherapy. Data analysis used SPSS-V۲۲ software, with statistical tests done at a significance level of < ۰.۰۵. Results: In total, ۱۲۸ neonates, comprising ۵۶ (۴۳.۸%) males and ۷۲ (۵۶.۲%) females, with a mean gestational age of ۳۹.۰۲±۰.۸۶ weeks and a mean age of ۲.۷۷±۱.۴۵ days, were subjected to analysis. After ۹۶ hours, the mean bilirubin level was ۹.۲۳±۲.۸۱ mg/dl overall, ۷.۲۷±۲.۱۲ mg/dl in the case group, and ۱۰.۹۱±۲.۱۷ mg/dl in the control group (p< ۰.۰۰۱). The mean time to reach a bilirubin level below ۱۰ mg/dl was ۵۱.۶۶±۱۷.۲۷ hours overall, ۵۸.۳۸±۱۰.۰۵ hours for the case group, and ۶۲.۶۱±۱۴.۳۹ hours for the control group (p< ۰.۰۰۱). Conclusion: Ursodeoxycholic acid (UDCA) effectively reduces elevated bilirubin levels and the duration of phototherapy when employed as an adjunct treatment to phototherapy in cases of infantile indirect hyperbilirubinemia.کلیدواژه ها
Hyperbilirubinemia, Jaundice, Phototherapy, Ursodeoxycholic acidاطلاعات بیشتر در مورد COI
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