Shayma L. Abdulhadi - Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Bab Al-Moadham, Baghdad, Iraq
Yasir F. Muhsin - Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Bab Al-Moadham, Baghdad, Iraq
Sumayah Saadi Abbas - Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Bab Al-Moadham, Baghdad, Iraq
Tagreed N. A. Omar - Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Bab Al-Moadham, Baghdad, Iraq

Coumarin pharmacophore is a six-membered aromatic heterocyclic, which is present in many natural products and synthetic molecules Coumarins, are widely abundant natural heterocyclic compounds, are extensively employed in creating various biologically potent substances. Coumarin sulfonamide hybrids are excellent compounds which have several applications in pharmacology; such as anti-inflammatory, antioxidant, anti-viral, anti-fungal, anti-bacterial, and anti-cancer properties. The many substitutions around the coumarin sulfonamide nucleus are outlined and by offering a broad range of pharmacological potential, have drawn the interest of numerous researchers that are trying to employ the coumarin sulfonamide hybrids in medication design and the creation of new medicinal compounds. A wide range of medicines, particularly in the fields of oncology and carbonic anhydrase inhibitors, are made possible by advancements in the synthesis and medicinal chemistry of compounds based on coumarin sulfonamide. The production and particular biological actions of several coumarin derivatives are the main topics of this review study. To find and create new synthetic strategies that could aid in structure-activity relationship (SAR) studies, certain innovative research approaches are also mentioned. The anticancer potential of coumarins has drawn attention from researchers recently because of their strong biological activity and low toxicity. Coumarins are frequently used to treat leukemia, prostate cancer, and renal cell carcinoma. They can also be used to reduce the negative effects of radiation therapy. Due to its therapeutic potential in cancer treatment and photo-chemotherapy, coumarin derivatives, both natural and synthetic, are gaining curiosity.

Coumarins, Sulfonamide, structure-activity relationship, anti-inflammatory, Antioxidant, Anti-viral, Anti-fungal, anti-bacterial, Anti-cancer activities