The purpose of this research was to teach mindfulness on distress tolerance, the meaning of lifeand marital relationships of mothers with mentally disabled children in Miandoab city. The present study was a semi-experimental study with a pre-test and post-test design with a control group.The statistical population includes all mothers with mentally retarded children in the city of Miandoab, whose number is ۱۷۰. In this research, ۳۰ mothers with mentally retarded children were selected as research samples using a simple random sampling method in the experimental group of mindfulness training (۱۵ people in each group) and the control group (۱۵ people). In order to collect data, the questionnaires of Stegro et al. (۲۰۰۶) and the meaning of life questionnaire of Simmons and Gaher (۲۰۰۵) were used. The statistical method of multivariate covariance analysis was used to analyze the data. The results showed that mindfulness training is effective on the distress tolerance of mothers with mentally retarded children. Mindfulness training on the meaning of life for mothers with intellectually disabled children is effective.