Emergence of Multidrug-Resistant and Extensively Drug-Resistant Non-Fermenting Gram-Negative Bacilli in a Tertiary Hospital in India

  • سال انتشار: 1403
  • محل انتشار: مجله میکروبیولوژی پزشکی و بیماریهای عفونی، دوره: 12، شماره: 2
  • کد COI اختصاصی: JR_JOMMID-12-2_004
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 116
دانلود فایل این مقاله

نویسندگان

Rinku Yadav

Department of Microbiology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India. Pin Code: ۱۲۴۰۰۱

Sonia Mehta

Department of Microbiology, B.R. Ambedkar State Institute of Medical Sciences, Mohali, Punjab, India. Pin Code: ۱۶۰۰۵۵

Rosy Bala

Department of Microbiology, M.M Institute of Medical Sciences & Research, Mullana, Haryana, India. Pin Code: ۱۳۳۲۰۷

Varsha Ashok kumar Singh

Department of Microbiology, Rajmata Vijaya Raje Scindia Government Medical College, Bhilwara, Rajasthan, India. Pin Code: ۳۱۱۰۰۱

Muskan Khullar

Department of Microbiology, District Hospital, Mohali, Punjab, India, Pin code: ۱۶۰۰۵۵

Parminder Singh

Government Civil Hospital, Kaithal, Haryana, India. Pin Code: ۱۳۶۰۲۷

چکیده

Introduction: Non-fermenting Gram-negative bacilli (NFGNB), particularly the Acinetobacter baumannii complex (ABC) and Pseudomonas aeruginosa, are common causes of infections in both hospitalized patients and outpatients, posing significant clinical and therapeutic challenges. The primary objective of this study was to conduct a comprehensive analysis of NFGNB, specifically ABC and P. aeruginosa, isolated from pus specimens obtained from both hospitalized patients and outpatients. Methods: This study investigated the antibiotic resistance patterns of NFGNB, focusing on ABC and P. aeruginosa, isolated from pus samples collected from both hospitalized patients and outpatients. The isolates were tested for multidrug resistance (MDR) and extensive drug resistance (XDR) using standardized microbiological protocols. The data were analyzed using descriptive statistics to summarize the findings. Results: Out of ۱۲۳۴ pus samples received, ۱۱۷ (۹.۵%) NFGNB were isolated, accounting for ۳۰% of the total Gram-negative bacilli (GNB) isolates. The majority of NFGNB (۸۲.۹%, n = ۹۷/۱۱۷) were isolated from inpatients, with surgical site infections being the most common clinical condition (۳۳.۳%, n = ۳۹/۱۱۷). Among the NFGNB isolates, P. aeruginosa was the predominant species (۷۶.۹%, n = ۹۰/۱۱۷), followed by A. baumannii (۲۲.۲%, n = ۲۶/۱۱۷). Antimicrobial susceptibility testing revealed that ۳۷.۷% (n = ۳۴/۹۰) of P. aeruginosa isolates were MDR and ۱۳% (n = ۱۲/۹۰) were XDR, while ۶۵% (n = ۱۷/۲۶) of A. baumannii isolates were MDR and ۲۶.۹% (n = ۷/۲۶) were XDR. Conclusion: This study highlights the emergence of NFGNB as significant nosocomial pathogens, exhibiting a high degree of resistance to commonly used antibiotics. The findings underscore the urgent need to enhance and strictly implement effective antibiotic stewardship policies, including the development of new antibiotic regimens and antimicrobial resistance surveillance programs, to combat the growing resistance of nosocomial pathogens and ultimately improve patient outcomes.

کلیدواژه ها

Acinetobacter baumannii, Multidrug-resistant (MDR), Extensive drug resistant (XDR), Non-fermenting Gram-negative bacteria (NFGNB), Pseudomonas aeruginosa

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.