Maryam Moazami - Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Mehrnoosh Sedighi - Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran
Marzieh Rashidipour - Nutritional Health Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran
Sara Haydari - Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Ghafar Ali Mahmoudi - Department of Internal Medicine, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Saber Ghaderpour - Department of Physiology, Tabriz Faculty of Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
Morteza Bakhshesh - Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran
Afshin Nazari - Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran
Maryam Moghimian - Department of Physiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

The purpose of this study is to evaluate a treatment for aluminum phosphide (ALP) poisoning, which is known as “rice tablet”. Methods: In the present study, the impact of different doses of ethanolic extract of olive leaves (۱۰۰, ۲۰۰, and ۴۰۰ mg/kg) on ALP (۱۲۰ mg/kg)-induced cardiotoxicity was evaluated in anesthetized-gastrotomized adult male Wistar rats. Thirty-five rats were randomly assigned into five groups (n=۷) as follows: control (AC) and treatment groups [ALP+Olea۱۰۰ (AO۱۰۰), ALP+Olea ۲۰۰ (AO۲۰۰), and ALP+Olea ۴۰۰ (AO۴۰۰)]. Physiological data including blood pressure, heart rate, electrocardiogram (ECG), as well as oxidative stress markers were measured in heart tissues. Results: ALP-intoxication led to perturbed normal ECG and increased oxidative stress. Administration of olive leaf extract at various concentrations, however, mitigated bradycardia after ۹۰ minutes, following ALP-intoxication (in AO۲۰۰), hypotension (in AO۱۰۰), and cardiac conduction disturbances (decreased QTC in the AO۲۰۰ ۳۰ (P<۰.۰۵), ۶۰ (P<۰.۰۰۱), and ۹۰ (P<۰.۰۵) minutes after intoxication)   and decreased PR ۶۰ (P<۰.۰۵) and ۹۰ minutes (P<۰.۰۱) after intoxication. This was compared with baseline as well as detrimental changes in cardiac electrophysiology [mitigated ST-segment elevation  in AO۲۰۰  and depressed T-wave in the AO۲۰۰ (P<۰.۰۵) and  AO۴۰۰ (P<۰.۰۱)  groups ۹۰ minutes after intoxication] Conclusion: Based on these authentic results, it seems that olive leaf extracts can be useful in reducing the severity of symptoms in ALP-poisoned individuals and could be utilized in a poisoning emergency.

Aluminum Compounds, Cardiotoxicity, Electrocardiography, Gastric lavage, Oxidative stress, Pesticides