Significance of FSHR and LHCGR gene polymorphisms on clinical outcomes in gonadotropin-releasing hormone antagonist protocol with freeze-all strategy: A case-control study
- سال انتشار: 1403
- محل انتشار: International Journal of Reproductive BioMedicine، دوره: 22، شماره: 7
- کد COI اختصاصی: JR_IJRM-22-7_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 114
نویسندگان
Wings IVF Women’s Hospital, Ahmedabad, Gujarat, India.
Wings IVF Women’s Hospital, Ahmedabad, Gujarat, India.
Wings IVF Women’s Hospital, Ahmedabad, Gujarat, India.
Wings IVF Women’s Hospital, Ahmedabad, Gujarat, India.
Wings IVF Women’s Hospital, Ahmedabad, Gujarat, India.
Life Fertility and Research Center, Collector Office Jn, Maharanipeta, Visakhapatnam, Andhra Pradesh, India.
Life Fertility and Research Center, Collector Office Jn, Maharanipeta, Visakhapatnam, Andhra Pradesh, India.
چکیده
Background: Follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/choriogonadotropin receptor (LHCGR) are integral to ovarian function, facilitating follicle development and maturation through their respective hormonal interactions. The influence of receptor polymorphisms on the outcomes of freeze-all cycles remains unclear. Objective: This study investigates the impact of FSHR N۶۸۰S and LHCGR N۳۱۲S polymorphisms on clinical outcomes in freeze-all cycles. Materials and Methods: Women undergoing controlled ovarian stimulation for assisted reproductive technology participated in this study. They were administered a gonadotropin-releasing hormone antagonist protocol, with recombinant follicle-stimulating hormone (rFSH) dosages adjusted according to age, body mass index, antral follicle count, and individual hormonal responses. Additionally, human menopausal gonadotropin dosages were tailored based on the LHCGR N۳۱۲S genetic variant. Results: Analysis revealed no significant differences in age, body mass index, antral follicle count, or marital status across the genotypes of FSHR N۶۸۰S and LHCGR N۳۱۲S. However, notable differences were observed in the rFSH dosage required daily and in total among the FSHR polymorphism genotypes. Genotypes of the LHCGR polymorphism correlated with fewer stimulation days. A significant interaction was observed between the ۲ polymorphisms concerning total rFSH dosage. Conclusion: The presence of serine in the FSHR polymorphism was associated with higher rFSH dosage requirements. Both FSHR N۶۸۰S and LHCGR N۳۱۲S polymorphisms significantly influenced clinical pregnancy and live birth outcomes in freeze-all cycles, underscoring the potential of a pharmacogenomic approach to optimize hormone supplementation in controlled ovarian stimulation protocols during assisted reproductive technology treatments.کلیدواژه ها
LHCGR, FSHR, Polymorphism., گیرنده هورمون لوتئینه کننده, گیرنده هورمون محرک فولیکول, پلی مورفیسم.اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.