Positive correlation between Bax and Bcl-۲ gene polymorphisms with the risk of endometriosis: A case-control study
- سال انتشار: 1403
- محل انتشار: International Journal of Reproductive BioMedicine، دوره: 22، شماره: 6
- کد COI اختصاصی: JR_IJRM-22-6_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 134
نویسندگان
Department of Obstetrics and Gynecology, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Obstetrics and Gynecology, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran.
Department of Cell and Molecular Biology, Kosar University of Bojnord, Bojnord, Iran.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
چکیده
Background: Endometriosis is a chronic, gynecological disorder, and the disease's pathogenesis is still debatable. Genes related to apoptosis have been revealed to be deregulated in endometriosis. Objective: This study investigates the relationship between polymorphic variants of Bax -۲۴۸G> A and Bcl-۲ -۹۳۸C> A promoter regions with endometriosis risk in an Iranian population. Materials and Methods: In this case-control study, the polymorphisms of Bax -۲۴۸G> A and Bcl-۲ -۹۳۸C> A promoter regions were analyzed in ۱۲۷ Iranian cases and ۱۲۵ controls who were referred to Ali-ibn-Abi Taleb Educational hospital, Zahedan, Iran between May ۲۰۲۲ and February ۲۰۲۳. The genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method. Results: The frequencies of mutant allele A carriers and the A allele of Bax -۲۴۸G> A polymorphism showed about ۲-fold significant increase of endometriosis risk (p = ۰.۰۴; p = ۰.۰۱, respectively). The frequencies of the mutant genotype AA and A allele carriers of Bcl-۲ -۹۳۸C> A polymorphism were approximately ۴ and ۲.۵-fold higher in endometriosis compared to the control women, which were highly significant (p > ۰.۰۰۱). Moreover, the allele A frequency of Bcl-۲ -۹۳۸C> A was associated with a ۲-fold higher risk of endometriosis (p > ۰.۰۰۱). Furthermore, the combination effects of these ۲ single nucleotide polymorphisms showed that women with Bax -۲۴۸G> A GG and Bcl-۲ -۹۳۸C> A AA variant alleles were associated with about ۵ times higher risk of endometriosis (p > ۰.۰۰۱). Notably, a significant difference was observed in mutant allele distribution between minimal/mild (stage I and II) and moderate/severe (stage III and IV) women with endometriosis disease. Conclusion: The results of our study provide evidence that Bcl-۲ -۹۳۸C> A and Bax -۲۴۸G> A single nucleotide polymorphisms might be associated with the risk of endometriosis.کلیدواژه ها
Endometriosis, Apoptosis, Genetic polymorphism, Bax, Bcl-۲., اندومتریوز, آپوپتوز, پلی مورفیسم ژنتیکی, Bax, Bcl-۲.اطلاعات بیشتر در مورد COI
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