A Comprehensive Review on Helicobacter pylori Infection and Gastric Cancer
- سال انتشار: 1400
- محل انتشار: فصلنامه ژنتیک و ژنومیک انسانی، دوره: 5، شماره: 1
- کد COI اختصاصی: JR_JHGG-5-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 165
نویسندگان
Department of Microbial Biotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran
Department of Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Department of Microbial Biotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran
Department of Biology, Faculty of Basic Sciences, Semnan University, Semnan, Iran
Seyed Amir Hossein Mohammadzadeh Hosseini Moghri
Department of Microbial Biotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran
چکیده
Background The Helicobacter pylori (H. pylori) is a spiral-shaped, gram-negative, motile and microaerophilic bacterium in which the human stomach is the single natural reservoir. Objectives This review study indicates the possible contribution of H. pylori infection as one of the recognized vital agents for the development of gastric malignancies. Methods Journal online databases such as Science Direct, PubMed, Google Scholar, and Wiley Online Library were investigated through keywords “Helicobacter pylori”, “Gastric Malignancy”, “Gene therapy” and “Nanotechnology”. Studies were subjected to the present review study if they met our relevance and quality criteria. Results We will discuss different virulence elements of H. pylori comprising cytotoxin-related gene A, vacuolating cytotoxin A, as well as various outer membrane proteins leading to malignancy through various mechanisms. Conclusions We also provide insight into the possible presence and role of a gastric malignancy stem cell in the tumors with the capability to initiate sustain self-renewal and tumor growth and novel strategies against H. pylori such as gene therapy, immunotherapy, immunoinformatics, antibiotic resistance, and nanotechnology aimed to provide a rationale view for new therapeutic approaches that are reviewed in the current study.کلیدواژه ها
Gastric Malignancy, Helicobacter pylori, immunoinformatics, Gene therapy, nanotechnologyاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.