Bacterial Spectrum and Antimicrobial Susceptibility Patterns in Septicemia Suspected Patients
- سال انتشار: 1403
- محل انتشار: فصلنامه عفونت، اپیدمیولوژی و پزشکی، دوره: 10، شماره: 3
- کد COI اختصاصی: JR_IEM-10-3_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 132
نویسندگان
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
چکیده
Backgrounds: In this comprehensive study, the prevalence of sepsis, a potentially life-threatening condition, was investigated among ۴۷۷ patients displaying sepsis symptoms. Materials & Methods: A detailed questionnaire was used to capture the patients' demographic information and clinical treatment outcomes.The E-test method was employed to determine the susceptibility of Gram-positive bacteria to vancomycin and Gram-negative bacteria to cefepime, ceftriaxone, and imipenem. Findings: Among the participants, ۴۰ patients (۸.۶%) were diagnosed with septicemia, a condition whose prevalence significantly increased with age (p= .۰۰۱). Out of ۴۰ patients with positive blood cultures, ۱۴ (۳۵%) were infected by Gram-positive bacteria, while ۲۶ (۶۵%) were infected by Gram-negative bacteria. Acinetobacter lwoffii and Staphylococcus epidermidis were identified as the most common causes of sepsis among Gram-negative (۳۰.۷%) and Gram-positive (۵۷.۱%) bacteria, respectively Gram-negative bacteria exhibited the highest resistance to ceftriaxone (۳۸.۴%) and the highest susceptibility to imipenem (۸۴.۶%) in both laboratory and clinical settings. Gram-positive bacteria demonstrated the high susceptibility to vancomycin (۷۸.۵%), with only four patients exhibiting resistance to vancomycin in both laboratory and clinical settings. Encouragingly, there was a ۷۷.۵% concordance between laboratory and clinical antibiotic susceptibility testing results. Conclusion: Based on these findings, vancomycin and imipenem are recommended as the preferred antibiotics for Gram-positive and Gram-negative bacteria, respectively. Given the high concordance (۷۷.۵%) between laboratory and clinical results, it is suggested to perform antibiogram test using E-test method on blood culture isolates in septicemia cases to guide appropriate antibiotic treatment.کلیدواژه ها
Septicemia, Clinical resistance, Bacterial agents, E-test method, Antibioticاطلاعات بیشتر در مورد COI
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