Evaluation of the efficacy of vitamin D in the treatment of oral lichen planus: A double-blind randomized clinical trial
- سال انتشار: 1400
- محل انتشار: مجله بهداشت دهان و دندان و اپیدمیولوژی دهان و دندان، دوره: 10، شماره: 2
- کد COI اختصاصی: JR_JOHOE-10-2_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 158
نویسندگان
Professor, Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Professor, Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Professor, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Professor, Department of Epidemiology and Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
Professor, Immunology Research Center, Inflammation and Inflammatory Diseases Division, Mashhad University of Medical Sciences, Mashhad, Iran
Associate Professor, Department of Immunology and Allergy, Academic Center for Education, Culture, and Research, Tehran, Iran
Medical Laser Research Center, Academic Center for Education, Culture and Research, Tehran, Iran
چکیده
BACKGROUND AND AIM: Oral lichen planus (OLP) is a chronic inflammatory and immune-mediated disease without a known etiology. Recent studies have indicated the role of vitamin D on immune system and proposed its anti-inflammatory effects. Present study aimed to evaluate the effect of vitamin D on the severity of pain, burning, and lesions of patients with OLP and serum levels of interleukin ۶ (IL-۶) and tumor necrosis factor alpha (TNF-α) after the intervention.METHODS: ۲۸ patients with OLP with vitamin D deficiency or insufficiency participated in this randomized double-blind, placebo-controlled clinical trial. They were divided into the two groups of intervention (n = ۱۳) and control (n = ۱۵). Serum levels of TNF-α, vitamin D, and IL-۶ were assessed before and ۸ weeks after the treatment. The intervention and control groups were given one capsule of ۵۰۰۰۰ units of vitamin D and one placebo capsule weekly for ۸ weeks, and they were also examined every other week, in terms of the severity of lesions (Thongprasom Index) and the severity of pain and burning [visual analog scale (VAS)]. The data analysis was carried out using SPSS statistical software and statistical tests included independent t-test, chi-square test, Mann–Whitney U-test, repeated measures test, and Pearson correlation coefficient test. The P-value < ۰.۰۵ was considered as significant.RESULTS: The severity of lesions was significantly reduced in the intervention group (P = ۰.۰۴۳). After the treatment, the mean IL-۶ levels significantly decreased in the intervention and control groups compared to pre-treatment conditions (P = ۰.۰۰۵ and P = ۰.۰۱۴, respectively). Moreover, the mean TNF-α concentrations significantly decreased only in the intervention group (P < ۰.۰۰۱).CONCLUSION: Vitamin D reduced the severity of OLP lesions, IL-۶, and TNF-α. Vitamin D can be suggested as adjuvant therapy for patients with OLP; however, further studies are required to confirm these effects.کلیدواژه ها
Vitamin D, Oral lichen planus, Interleukin-۶, Tumor Necrosis Factor, visual analog scaleاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.