Impact of Opium Addiction on Levels of Pro- and Anti-inflammatory Cytokines after ‎Surgery

Background: Opium addiction alters immune responses to stresses such as an injury due to changing the secretion of cytokines. The present study assessed the effect of opium addiction on the cytokines [tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), interleukin-۴ (IL-۴), and IL-۱۰] before and after laparotomy. Methods: Male rats were randomly divided into control and opium addicted (n = ۲۰). Then, cytokines were measured before surgery, immediately after surgery (within ۳۰-۶۰ minutes) and ۲۴ hours after surgery. Findings: IFN-γ was raised in an addicted group in three phases of the study as compared to that of the control group. IL-۴ in opium addicted group decreased in two phases after surgery compared to the control group. IL-۴ was lower after surgery in comparison to before surgery in the opium addicted group. The difference in IL-۱۰ and TNFα levels was not statistically significant in the all groups measured in three phases of the investigation. Conclusion: The results revealed that opium addiction can increase plasma level of IFN-γ in rats and decrease plasma level of IL-۴ after surgical stress. It seems that opium addicted rats are a more susceptible to increased inflammation.

کلیدواژه ها:

Cytokines ، Interleukins ، opium addiction ، laparotomy ، Rat‎