Farhad Iranmanesh - Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Rostam Syfadini - Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Yaseman Mahalati - Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Faranak Gadari - Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Tania Dehesh - Department of Biostatistics and Epidemiology, School of Health, Kerman University of Medical Sciences, Kerman, Iran

Background: There is no consensus on the effect of opium on stroke yet. Some studies show the negative effects of opium on ischemic strokes. Here, we attempt to compare the volume of lesions in opium addict and non-addict patients with thrombotic stroke. Methods: This case-control study was conducted on patients with thrombotic stroke at Shafa Hospital in Kerman, Iran. The diagnosis was confirmed by clinical examinations, imaging, and laboratory tests. The volume of lesions was calculated by magnetic resonance imaging (MRI), and the data were analyzed by descriptive statistics, Mann-Whitney U test, Chi-square test, and linear regression analysis. Findings: A total of ۶۰ patients were studied, ۳۰ of whom were opium addicts and the rest were non-addicts. The mean volume of the lesion was ۴۶.۰۰۸۳۵۰ ± ۷.۴۸۸۹۹۰ (in the addict group) and ۳۱.۰۲۳۳۳۵ ± ۱.۴۴۱۵۷۰ (in the non-addict group), indicating a significant difference between the two groups (P = ۰.۰۰۵). Regression analysis results showed a significant relationship between the volume of stroke with opium addiction (P = ۰.۰۱۷), ischemic heart diseases (IHDs) (P = ۰.۰۰۶), hyperlipidemia (HLP) (P = ۰.۰۱۶), age (P = ۰.۰۳۵), and smoking (P = ۰.۰۴۴). Conclusion: The results of this study showed a higher volume of lesion in opium-addict patients compared to that in non-addicts as an indicator of stroke severity.

Opium, Thrombotic stroke, Magnetic resonance imaging