Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice

  • سال انتشار: 1402
  • محل انتشار: مجله اعتیاد و سلامت، دوره: 15، شماره: 3
  • کد COI اختصاصی: JR_AHJK-15-3_005
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 167
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نویسندگان

Katayoon Arjmand

Masters student, Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Erfan Daneshi

Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Soheila Pourmasumi

Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Fardin Fathi

Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Sherko Naseri

Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Parvin Sabeti

Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

چکیده

Background: Morphine is a narcotic pain reliever that is prescribed to reduce postoperative pain and can produce reactive oxygen species (ROS). Therefore, it can have negative effects on spermatogenesis and male fertility. Vitamin E is an effective antioxidant which plays an important role in membrane lipid peroxidation due to increased ROS. The present study aimed to evaluate the effects of vitamin E and morphine on sperm parameters, level of malondialdehyde (MDA), and diameter of seminiferous tubules in morphine-treated mice. Methods: In this experimental study, ۸۰ mice were divided into ten groups (n=۸) including control, normal saline, vehicle, morphine, various doses of vitamin E (۱۰۰, ۲۰۰, ۳۰۰ mg/kg), and morphine plus vitamin E (۱۰۰, ۲۰۰, ۳۰۰ mg/kg) groups. The groups were followed up for ۳۰ consecutive days. Sperm parameters, testis weight, the diameter of seminiferous tubules, and the level of MDA were analyzed and compared.Findings: Data analysis showed seminal parameters decreased significantly (excluding sperm count) and there was an increase in the level of MDA in morphine-treated mice compared with the normal saline group (P< ۰.۰۵). Administration of E۱۰۰ to morphinetreated mice did not show a significant difference in the evaluated parameters compared with the morphine group. However, E۲۰۰ and E۳۰۰ significantly reduced MDA and improved sperm parameters (P≤۰.۰۵).Conclusion: The results showed co-administration of vitamin E in high doses (۲۰۰ & ۳۰۰) could prevent the deleterious effects of morphine on some reproductive parameters and decrease the level of MDA in morphine-treated mice.

کلیدواژه ها

Morphine, Male infertility, Sperm parameters, Malondialdehyde

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