Mohammad Norouzi - Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran -Department of Nanotechnology and Tissue Engineering, Stem Cell Technology Research Center, Tehran, Iran
Iman Shabani - Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran -Department of Nanotechnology and Tissue Engineering, Stem Cell Technology Research Center, Tehran, Iran
Fatemeh Atyabi - Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Masoud Soleimani - Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

In this study, nanofibrous scaffolds of poly(lactic-co-glycolic acid) (PLGA) through electrospinning technique were fabricated. Also, PLGA nanofibers with a core-sheath structure encapsulating bovine serum albumin (BSA) as a model protein for hydrophilic bioactive agents were prepared through emulsion electrospinning technique. Morphology of the nanofibers and the core-sheath structure of the emulsion electrospun nanofibers were observed by field-emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM), respectively. The results of protein release assay demonstrated a sustained release profile of BSA. The nanofibrous scaffold with the capability of encapsulation and controlled release of the protein can be served in tissue engineering applications.

Emulsion electrospinning, Nanofibrous scaffold, Controlled release, PLGA