Mohammed Amin Latif - Image Analysis Lab., Radiology Department, Henry Ford Health System, Detroit, Michigan, USA
Abbas Bahajani Feremi - Image Analysis Lab., Radiology Department, Henry Ford Health System, Detroit, Michigan, USA
Daniel Barkmeier - The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
Jeffery A Leob - The Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA

The gold standard for the localization of epileptic activities in the cerebral cortex is intracranial electrocorticography (ECoG) electrodes placed directly on the brain surface. However, it has limitations in being able to localize deep brain epileptic sources. As a means to improve the localization of epileptic activities from these subdural electrical recordings, we developed a simple source monitoring system to detect and localize these deep sources. The method is based on an independent component analysis (ICA) algorithm known as jointapproximate diagonalization of eigen-matrices (JADE). This method was tested on patients with neocortical epileptic foci focusing on the interictal spikes from ECoG signals. The proposed method localizes the interictal epileptic discharges to both superficial as well as deep regions of the human neocortex and has the potential to improve the localization and surgical outcomes of patients with medically refractory epilepsy undergoing surgical resections.

independent component analysis (ICA); joint approximate diagonalization of eigen-matrices (JADE); intracranial electrocorticography (ECoG); interictal spikes (IIS)