Mohammad Ghorbani - Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Saeid Esmaeilian - Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran
Elham Rahmanipour - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Ramin Sadeghi - Department of Nuclear Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Aryan Zahergivar - Radiology and Imaging Sciences Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States
Roham Nikkhah - Isfahan Medical Students Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
Emran Askari - Department of Nuclear Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Amirali Aali - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Mirzaei - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Vahid Reza Dabbagh Kakhki - Department of Nuclear Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Mahyar Daskareh - Department of Radiology, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran

Introduction: The coronavirus disease ۲۰۱۹ (COVID-۱۹) pandemic has posed a major challenge to the diagnosis and management of ischemic heart disease (IHD). Myocardial perfusion imaging (MPI) is a non-invasive technique that can assess myocardial ischemia and viability, as well as provide prognostic information for patients with IHD. However, the role of MPI in COVID-۱۹ patients is not well established.Methods: A comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science was conducted to identify relevant studies published until Aprile ۲۴th, ۲۰۲۴. The inclusion criteria were: (۱) studies that performed MPI in COVID-۱۹ patients; (۲) studies that reported the results of MPI in terms of ischemia, infarction, or perfusion defects; and (۳) studies that compared MPI with other diagnostic modalities or clinical outcomes. The quality of the studies was assessed using the QUADAS-۲ tool for diagnostic accuracy studies or the ROBIS tool for systematic reviews. A narrative synthesis was performed to summarize the main findings and recommendations.Results: A total of twenty-two studies met the inclusion criteria. The included study information was categorized into the following aspects: Change in the crude number of MPI scans performed, accidental and definite findings in MPI, and the prognostic outcome of COVID patients who underwent MPI.Conclusion: During Covid-۱۹ pandemic a reduction in the number of MPI studies was seen. Individuals with a history of COVID-۱۹ infection have higher likelihood of developing ischemic heart disease (IHD). SARS-CoV-۲ is an independent risk factor for the development of IHD.

Myocardial perfusion imaging, Covid-۱۹, Ischemic heart disease, SPECT