Protective role of resistance training against cisplatin-induced oxidative stress in rats

  • سال انتشار: 1402
  • محل انتشار: شانزدهمین کنفرانس بین المللی بهداشت، درمان و ارتقای سلامت
  • کد COI اختصاصی: HWCONF16_015
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 220
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نویسندگان

Mohammad Parastesh

Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran.Research Institute of Applied Studies of Sports Sciences, Arak University, Arak, Iran.

Hamidreza Khaluonejad

M.S. in Exercise Physiology, Department of Exercise Physiology, Arak University, Arak, Iran.Corresponding Author, Department of Exercise Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran.

چکیده

Background and purpose: this study aimed to investigate the effect of resistance training (RT) on oxidative stress and total antioxidant capacity in rats treated with cisplatin.Materials and methods: In this experimental study, ۲۱ Sprague Dawley rat models were randomly divided into three groups: control (n=۷), control cisplatin (n=۷), and cisplatin with RT (n=۷). In cisplatin groups, ۱۰mg/kg cisplatin was injected intraperitoneally. The training groups also performed the training for ten weeks. Twenty-four hours after the last training session, the blood serum of rats was collected to examine the desired variables. Data were analyzed using one-way analysis of variance at the significant level of P≤۰.۰۵.Results: In this study, cisplatin injection caused a significant increase in malondialdehyde (MDA) (P=۰.۰۰۱), a substantial decrease in total antioxidant capacity (TAC) (P=۰.۰۰۱), and a considerable reduction in catalase (CAT) in the control group. Compared to cisplatin control. Malondialdehyde (MDA) was also significantly reduced in the cisplatin group with RT (P=۰.۰۰۱) compared to the control group. In addition, no significant difference was observed in total antioxidant (TAC) in the cisplatin group with RT (P=۰.۲۲۷) compared to a healthy control group. Also, catalase (CAT) in the cisplatin group with RT (P=۰.۴۰۴) was not significantly different from the control group.Conclusion: It seems that exercise with different intensities can effectively reduce the oxidative stress conditions caused by cisplatin in rats.

کلیدواژه ها

Resistance training; Cisplatin; Oxidative stress; Malondialdehyde

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