In situ green biosynthesis of palladium nanoparticles by usingGinger/Pectin as plant mixture: investigation of its catalyticefficiency in the Sonogashira cross coupling reaction

سال انتشار: 1402
محل انتشار: دومین همایش ملی گیاهان دارویی، کارآفرینی و تجاری سازی
کد COI اختصاصی: MPEC02_161
زبان مقاله: انگلیسی
تعداد مشاهده: 127

نویسندگان

Department of Chemistry, Payame Noor University (PNU), P.O. Box ۱۹۳۹۵-۳۶۹۷, Tehran, Iran

چکیده

Among the wide range of reactions in synthetic organic chemistry, the C-C coupling reactions are protagonist.Different reactions under this category such as Suzuki-Miyaura, Heck, Sonogashira, Hiyama, Kumada,Negishi, Stille and Fukuyama coupling are utilized as powerful tools towards thesynthesis of differentsynthetic intermediates, heterocycles, polymers, drugs, ligands and dendrimers (Shahriari M. et al ۲۰۲۲).TheSonogashira coupling reaction of terminal alkynes and aryl or alkenyl halides provides an efficient method tothe synthesis of aryl alkynes. This reaction is performed in the presence of catalytic amounts of a palladiumcomplex and copper (I) iodide in the presence of a base. Using copper iodide as the co-catalyst sometimes leadto the homo-coupling reaction of terminal alkynes (Khazaei A., et al. ۲۰۱۳).The ginger has a powerful fragrance and is used globally as a spice, flavoring, or fragrance in foods, beverages,soaps, cosmetics, and more prominently as medicine, including Coronavirus disease. It has antioxidant andantibacterial properties and is used for stomach ache, cough and exclusively reduces the severity of acutechemotherapy-induced nausea in adult cancer patients (Mehata M.S. ۲۰۲۱). Pectin is a polysaccharide that isfound extensively in all plant primary cells. It is a natural polymer which extensively employed in foodindustry, as a thickener or stabilizing agent. Pectin is a linear chain of ۱,۴-linked α-D-galacturonic acid residuesin which some of the carboxyl groups are methyl esterified (Figure ۱). Eye-catching properties of pectin, suchas flexibility, biodegradability, non-toxicity, low price and carrying freely available hydroxyl groups make itsuitable and ideal candidate for many practices in different areas of science (Ridley B.L. et al. ۲۰۰۱). Pectincontains free carboxyl groups on its backbone which can form complexes with Pd(II) ions in solution andreduce them to Pd(۰) without using any extra reducing agent such as NaBH۴, hydrazine or molecular hydrogen.This slow rate in situ reduction of Pd(II) to Pd(۰) causes the formation of small size and well distributedpalladium nanoparticles on the surface of mixture ginger and pectin (Khazaei A., et al. ۲۰۱۳).

کلیدواژه ها

Palladium nanoparticles, Ginger, Pectin, Sonogashira, Catalyst

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