Mohammad Sadegh Tahmtan - Yasouj University
Zahra Rafeei - Yasouj University

Over the past decade, remarkable progress has been made in developing scaffolds from natural or syntheticcomposites or hybrid biomaterials to enhance wound healing, bone fracture repair, and treating bone loss dueto pathology. However, the challenges associated with using these scaffolds in tissue engineering includelimited cellular proliferation, inadequate differentiation, low mechanical stability, and insufficient bioactivity.Recent advancements in fabricating nanoscale metal-organic framework (nano-MOF) scaffolds havepresented significant opportunities to improve the properties of scaffolds used in bone and wound tissueengineering. Recent studies have shown that adding nano-MOFs to scaffolds can help damaged tissues growback in a big way. These nano-MOFs have special properties, such as a large internal surface area, manyholes, strong mechanical stability, biocompatibility, and adjustability.Another thing is that the nanoscalestructural and topological features of nano-MOFs improve the physicochemical properties of scaffolds. Thismeans they can carry drugs and release ions while controlling how stem cells attach, multiply, anddifferentiate after transplantation. This review provides an overview of the various nano-MOFs incorporatedinto scaffolds for tissue engineering and comprehensively discusses their recent applications in bone andwound healing. Yaghi and colleagues created the zeolitic imidazolate frameworks (ZIFs), a subclass ofMOFs that exhibit exceptional hydrothermal and thermal properties and chemical stability. We look into theunique features of nano-ZIF-۸ that help improve osteoconductivity, osteoinductivity, and wound healing.These features include its strong antibacterial activity, high drug loading capacity (for example, bioactivemolecules and growth factors), and controlled drug release. Finally, the review addresses the challenges,clinical obstacles, and considerations for integrating these nanomaterials into various scaffolds, tissue-likestructures, implants, fillers, and dressings used in orthopedic and wound care clinics. The quest for effectivebone regenerative scaffolds has led to many fabrication methods being explored and reported in the scientificliterature. This article provides an overview of these fabrication techniques, highlighting their advantages andpotential weaknesses. The parts of scaffolds, the different ways they can be made, in vivo and ex vivo testson scaffolds, articles about using zeolite nanostructures, and how well they work in scaffolds are all reviewedin this review.

nanoparticles, ZIF-۸, bone regeneration, bone scaffolds