Hamidreza Hassanzadeh Khanmiri - Department of Basic Sciences, Maragheh Branch, Islamic Azad University, Maragheh Iran
Anas Amer Mohammad - Anaesthesia and Intensive Care Medicine, Department of Medical Education, College of Medicine, University of Duhok, Region of Kurdistan, Iraq
Reber Saeed Yousif - Specialist Neurosurgeon Duhok Emergency Teaching Hospital, Duhok, Kurdistan Region, Iraq
Saade Abdalkareem Jasim - Al-maarif University College, Medical Laboratory Techniques Department, Al-anbar-Ramadi, Iraq
Hamzah H. Kzar - Veterinary medicine College, Al-Qasim green University, Al-Qasim, Iraq
Methaq Hadi Lafta - Iraqi Ministry of Education, Iraq
Abduladheem Turki Jalil - Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla, ۵۱۰۰۱, Iraq
Rosario Mireya Romero Parra - Universidad Continental, Lima, Perú
Mohammad Darvishi - Faculty of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran

The severe acute respiratory syndrome coronavirus ۲ (SARS-CoV-۲) has the same sequence as SARS-CoV and has been reported with clinical symptoms similar to those of SARS-CoV and MERS-CoV. This study reviewed the neuro-invasive potential of SARS-CoV۲ reported in various studies. We searched keywords containing COVID-۱۹, coronavirus, respiratory infection, SARS‐CoV۲, and neuro-invasive potential in PubMed, WOS, Scopus, SID, and Google scholar. The results of our study led to the achievement of articles on the study of COVID-۱۹. This study focused on published articles from ۱۹۷۰ to ۲۰۲۱. Respiratory failure was drawn as the most prominent symptom of COVID-۱۹, while evidence suggests that SARS-CoV۲ does not exclusively affect the respiratory system and may lead to neurological disease by invading the central nervous system. SARS-CoV may also cause severe brainstem infection. Some coronaviruses (CoVs) can spread through a synaptic connection to the medullary cardiorespiratory center of mechanical and chemical receptors in the lungs and lower respiratory tract. Neuro-invasive and neurotropic tendency of SARS-CoV۲ has potential to cause neuropathological issues in the patients. Since there are many similarities between SARS-CoV and SARS-CoV۲, recognizing the link between potential SARS-CoV۲ virus attack and acute respiratory failure in COVID-۱۹ infection is critically important in preventing and treating SARS-CoV-۲ respiratory failure.

Coronavirus, Outbreak, Acute respiratory failure, Nervous system, MERS-CoV, Neurotropic, SARS-CoV۲