SARS-CoV۲ neuroinvasive potential in respiratory failure in COVID-۱۹ patients

  • سال انتشار: 1402
  • محل انتشار: مجله علوم زیستی خاورمیانه، دوره: 21، شماره: 2
  • کد COI اختصاصی: JR_CJES-21-2_023
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 51
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نویسندگان

Hamidreza Hassanzadeh Khanmiri

Department of Basic Sciences, Maragheh Branch, Islamic Azad University, Maragheh Iran

Anas Amer Mohammad

Anaesthesia and Intensive Care Medicine, Department of Medical Education, College of Medicine, University of Duhok, Region of Kurdistan, Iraq

Reber Saeed Yousif

Specialist Neurosurgeon Duhok Emergency Teaching Hospital, Duhok, Kurdistan Region, Iraq

Saade Abdalkareem Jasim

Al-maarif University College, Medical Laboratory Techniques Department, Al-anbar-Ramadi, Iraq

Hamzah H. Kzar

Veterinary medicine College, Al-Qasim green University, Al-Qasim, Iraq

Methaq Hadi Lafta

Iraqi Ministry of Education, Iraq

Abduladheem Turki Jalil

Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla, ۵۱۰۰۱, Iraq

Rosario Mireya Romero Parra

Universidad Continental, Lima, Perú

Mohammad Darvishi

Faculty of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran

چکیده

The severe acute respiratory syndrome coronavirus ۲ (SARS-CoV-۲) has the same sequence as SARS-CoV and has been reported with clinical symptoms similar to those of SARS-CoV and MERS-CoV. This study reviewed the neuro-invasive potential of SARS-CoV۲ reported in various studies. We searched keywords containing COVID-۱۹, coronavirus, respiratory infection, SARS‐CoV۲, and neuro-invasive potential in PubMed, WOS, Scopus, SID, and Google scholar. The results of our study led to the achievement of articles on the study of COVID-۱۹. This study focused on published articles from ۱۹۷۰ to ۲۰۲۱. Respiratory failure was drawn as the most prominent symptom of COVID-۱۹, while evidence suggests that SARS-CoV۲ does not exclusively affect the respiratory system and may lead to neurological disease by invading the central nervous system. SARS-CoV may also cause severe brainstem infection. Some coronaviruses (CoVs) can spread through a synaptic connection to the medullary cardiorespiratory center of mechanical and chemical receptors in the lungs and lower respiratory tract. Neuro-invasive and neurotropic tendency of SARS-CoV۲ has potential to cause neuropathological issues in the patients. Since there are many similarities between SARS-CoV and SARS-CoV۲, recognizing the link between potential SARS-CoV۲ virus attack and acute respiratory failure in COVID-۱۹ infection is critically important in preventing and treating SARS-CoV-۲ respiratory failure.

کلیدواژه ها

Coronavirus, Outbreak, Acute respiratory failure, Nervous system, MERS-CoV, Neurotropic, SARS-CoV۲

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