Effects of xenostrogen treatment (۴-Nonylphenol, Bisphenol A) on vitellogenin expression in juvenile Cyprinus carpio
- سال انتشار: 1398
- محل انتشار: مجله علوم زیستی خاورمیانه، دوره: 17، شماره: 1
- کد COI اختصاصی: JR_CJES-17-1_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 195
نویسندگان
Department of Environmental Sciences, Faculty of Natural Resource and Environment, Malayer University, Hamedan, Iran
Department of Environmental Sciences, Faculty of Natural Resource and Marine Science, Tarbiat Modares University, Noor, Mazandaran, Iran
Department of Environmental Sciences, Faculty of Natural Resource and Marine Science, Tarbiat Modares University, Noor, Mazandaran, Iran
Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Department of Environmental Sciences, Faculty of Natural Resource and Environment, Malayer University, Hamedan, Iran
چکیده
The aim of this study was to examine some potential effects of ۴-Nonylphenol (۴-NP), Bisphenol A (BPA), and mixture of them on common carp, Cyprinus carpio and demonstrate induction of vitellogenin (Vtg) as a biomarker for screening aquatic ecosystems. These compounds with other estrogenic chemicals may be responsible for disrupting effects observed in fish. A total of ۱۰۰ juvenile carp were treated experimentally with ۱۷β-estradiol (E۲), and increasing doses of ۴-NP, BPA and also mixture of them. Then the plasma Vtg levels were measured using indirect competitive ELISA. Results showed a significant (P< ۰.۰۵) increase in Vtg levels of exposed carps with E۲, maximum ۴-NP, BPA and their mixture. The group treated with E۲ showed high induction (۴۹۰%) with respect to controls. The groups treated with maximum dose of ۴-NP and BPA showed also induction of Vtg, whereas the group treated with their mixture (۳ mg kg−۱ b.w. ۴-NP and ۰.۰۱ mg kg−۱ b.w. BPA) showed the highest induction (۲۱۲۶%). Finally, results showed that mixture of ۴-NP and BPA exhibited stronger (synergistic) effects. So that, large scale monitoring of estrogenic effects caused by contamination may be considered as a biomarker in urban and industrial effluents.کلیدواژه ها
Vitellogenin (Vtg), Cyprinus carpio, ۱۷β-Esteradiol (E۲), ۴-Nonylphenol (۴-NP), Bisphenol A (BPA), ELISAاطلاعات بیشتر در مورد COI
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