Evaluating Immunomodulatory Effects and Cytokine Changes by Propranolol Following Surgical Stress in Male Rats
- سال انتشار: 1403
- محل انتشار: فصلنامه طب دامی ایران، دوره: 18، شماره: 3
- کد COI اختصاصی: JR_IJVM-18-3_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 122
نویسندگان
Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Department of Basic Sciences and Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Basic Sciences and Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
چکیده
Background: Surgery through different mechanisms causes immunosuppression in the postoperative period. Objectives: This study aimed to investigate the effects of preoperative administration of propranolol on blood levels of interleukin-۲ (IL-۲), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and hematological parameters, such as white blood cells (WBCs) and lymphocytes. Methods: Forty-five Wistar male rats were divided into three groups. Group ۱ (normal control) was injected with normal saline. Groups ۲ and ۳ were injected subcutaneously with ۴ mg/kg of the propranolol (P۴) and ۸ mg/kg of the propranolol (P۸), respectively. Blood samples were collected (before, immediately, ۶, ۲۴, and ۷۲ hours after surgery). Then, the IL-۲, IFN-γ, TNF-α, WBCs, and lymphocytes levels were determined at different time points. The data were analyzed by one-way ANOVA and the Pearson-test at a significant level of P≤۰.۰۵. Results: The results showed a higher level of IL-۲ in the P۸ and P۴ groups with a significant difference compared to the control group (P≤۰.۰۵). TNF-α was decreased significantly in the P۸ compared to the P۴ and control groups (P≤۰.۰۵). The P۴ has shown a lower level of IFN- γ compared to the P۸ and control groups with a significant difference (P≤۰.۰۵).Conclusion: It appears that propranolol has considerable immunomodulatory effects on immune responses. Therefore, perioperative use of propranolol may improve immune system function.کلیدواژه ها
Interleukin-۲, Interferon-γ, Tumor necrosis factor-α, Propranolol, Surgical Stressاطلاعات بیشتر در مورد COI
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