Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in Rat
محل انتشار: دوفصلنامه جراحی دامپزشکی، دوره: 16، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 86
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شناسه ملی سند علمی:
JR_IJVS-16-1_003
تاریخ نمایه سازی: 8 خرداد 1403
چکیده مقاله:
Injury and degeneration of tendons can be highly debilitating and can result in substantial pain, disability, and healthcare costs. Nano-sized fibers have a much wider surface area than conventionally produced fibers, which can hold composite materials more compactly and thus provide greater mechanical capabilities. In this study, the injured tendon was treated by electrospun PVA mats containing eucalyptus extract and histopathological results of healing were evaluated. For this study, ۴۵ male Wistar rats were prepared and a partial thickness tenotomy was created on right hindlimbs. All rats were divided into three groups (n = ۱۵) and three sub-groups (n = ۵) including, eucalyptus extract-loaded nanofibers, PVA nanofibers, and without any treatment as a control group. Histological samples were taken on days ۱۴, ۲۸, and ۴۲. The histological analysis on day ۱۴ indicated no significant difference was observed between all groups (p > ۰.۰۵). While on days ۲۸ and ۴۲ post-rupture indicated a higher regenerating activity and capacity in the eucalyptus extract-loaded nanofibers than PVA nanofiber and control groups (p ≤ ۰.۰۵). In summary, these results suggest that the eucalyptus extract-loaded nanofibers mats promoted the healing process of damaged Achilles tendon in rats.
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نویسندگان
Seyed Mohammad Ali Sadat-Hosseini
DVM Graduated, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
Hamid Reza Moslemi
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
Mohammad Sadegh Nourbakhsh
Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan, Iran.
Sahar Ghaffari-Khaligh
Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
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