Evaluation of Hydroalcoholic Extract of Licorice Root (Glycyrrhiza glabra L.) on Wound Healing of Gastrotomized Male Wistar Rats: Histopathological Changes

  • سال انتشار: 1400
  • محل انتشار: دوفصلنامه جراحی دامپزشکی، دوره: 16، شماره: 2
  • کد COI اختصاصی: JR_IJVS-16-2_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 59
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نویسندگان

Aida Golmohammadii

Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

Abdolrasoul Namjou

Department of Pathology, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

Esfandiar Heidarian

Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

چکیده

This study investigated the effects of hydro-alcoholic extract of licorice root on the healing of surgical gastric ulcers in rats. For this experimental study, thirty-six male Wistar albino rats were prepared, and first, a ۱۶ mm incision was made in the greater curvature of the stomach, and then it was sutured in a single layer. The rats were then randomly distributed into three groups (n=۱۲), a control group, and two other groups, which were treated with licorice hydroalcoholic extract at doses of ۱۵۰ and ۳۰۰ mg/kg orally via gavage once daily for ۲۱ consecutive days. Wound healing among the groups was compared and a determination was made for the malondialdehyde (MDA) concentration and serum antioxidant capacity. The mean rank of histopathological evaluation on the twentieth day after surgery showed a significant difference between the three groups. The difference in mean rank showed a significant increase between the group of rats treated with the extract at a dose of ۳۰۰ mg/kg compared to the control group. The amount of MDA in the control group showed a significant increase compared to the groups treated with the extract at doses of ۱۵۰ and ۳۰۰ mg/kg. Serum antioxidant capacity in the experimental group treated with extracts showed a significant increase in comparison with the control group. The results of this study showed that lipid peroxidation in a gastrotomy rat treated with licorice root hydroalcoholic extract decreased with a marked increase in antioxidant activity and subsequently accelerated the healing process of the gastric surgery site.

کلیدواژه ها

Antioxidant Capacity, Greater curvature, Malondialdehyde, stomach, Surgery

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