Histopathologic Evaluation of Intraperitoneal Administration of Cerium Oxide Nanoparticles on Ischemia Reperfusion Injury in Rat Testicular Torsion and Detorsion Model

سال انتشار: 1400
محل انتشار: دوفصلنامه جراحی دامپزشکی، دوره: 16، شماره: 2
کد COI اختصاصی: JR_IJVS-16-2_002
زبان مقاله: انگلیسی
تعداد مشاهده: 127

نویسندگان

Department of Pathology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.

چکیده

Testicular torsion and detorsion are important clinical problems for infertility in men. In fact, torsion of the spermatic cord is an emergency that results from the rotation of the testis and epididymis around the axis of the spermatic cord. Male factor infertility accounts for up to half of all cases of infertility and affects one man in ۲۰ in the general population. Using a rat testis model, effects of cerium oxide nanoparticles (NCER) were studied on ischemia-reperfusion injury. Eighteen healthy male Wistar rats were used. The animals were subjected to three experimental groups (n = ۶): Group Sham: Only laparotomy was performed. Group IS/REP: A ۳- hour ischemia and ۳-hour reperfusion were performed. Group IS/REP/NCER: The procedure included ۳-hour ischemia, ۳-hour reperfusion, and ۲۰ µL (۰.۳ mmol/lit) of NCER ۳۰ min before the cessation of ischemia. Significantly amended development of ischemia/reperfusion tissue injury was observed in animals treated with NCER compared to those of other groups (p = ۰.۰۰۱). Mean values of histomorphometric indices were significantly more improved than those observed for other groups (p = ۰.۰۰۱). Where testicular tissue is exposed to ischemia intraperitoneal administration of NCER could bear clinical benefits in diminishing ischemia-reperfusion injury.

کلیدواژه ها

Cerium oxide nanoparticles, ischemia-reperfusion, Intraperitoneal, Testis

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.