Investigating the Effect of Pentoxifylline and Zinc Oxide Combination on Experimental Full-Thickness Wound Healing in Rats
- سال انتشار: 1402
- محل انتشار: دوفصلنامه جراحی دامپزشکی، دوره: 18، شماره: 1
- کد COI اختصاصی: JR_IJVS-18-1_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 125
نویسندگان
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Department of Basic Siences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
چکیده
This paper aims to investigate the effect of topical application of pentoxifylline and zinc oxide combination on experimental full-thickness wound healing in rats. Forty-eight adult male Wistar rats weighing ۲۵۰ to ۳۰۰ g were randomly divided into four groups of ۱۲: Control (C), Zinc oxide (Z), Pentoxifylline (P), and Zinc-Pentoxifylline (ZP). For topical use of pentoxifylline, the ointment was formulated as ۵%. All rat were anesthetized by intraperitoneal administration of a combination of xylazine ۲% and ketamine ۱۰% and after transfer to the operating table, under aseptic conditions, using a sterile ruler and surgical razor, a ۲×۲ cm۲ skin defect in the back was created. In order to manage the wound, each group received appropriate treatment. In the ZP group, the combination of pentoxifylline and zinc oxide was treated in a ratio of ۱:۱. On days ۷, ۱۴, and ۲۱ after facilitation, a subgroup of each main group was sampled, then the samples were examined macroscopically and microscopically. At the end of this period, the highest percentage of the healing, wound closure, and keratinocyte migration and the lowest inflammation belonged to the PZ group. The rate of inflammation and the number of inflammatory cells at the end of the period were lower in the ZP group than Z group and there was a statistically significant difference (p ≤ ۰.۰۵). Overall, this study showed that wound healing is performed with better speed and quality following topical application of a combination of zinc oxide and pentoxifylline. However, more studies are needed to confirm this conclusion.کلیدواژه ها
Zinc oxide, pentoxifylline, wound healing, Ratاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.