Mahdie Jajroudi - Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Milad Enferadi - Department of Radiology and Biomedical Imaging, Yale School of Medicine, PO Box ۲۰۸۰۴۸, New Haven, CT, ۰۶۵۲۰-۸۰۴۸, USA.
Zahra Bagherpour - Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Reza Reiazi - Department of Radiation Physics, Division of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX ۷۷۰۳۰, USA

Introduction: Breast cancer is the most common cancer among women worldwide. Early detection of breast cancer reduces mortality and morbidity. Acquiring or identifying valuable information in the form of rules is the key to an accurate diagnosis and differentiation between benign and malignant breast cancers. Our goal is to find the hidden but beneficial knowledge in the form of rules from datasets. In this paper, we use association rule mining algorithms to obtain information in the form of data rules for differential diagnosis between benign and malignant breast masses based on radiomic features, extracted from mammography images. Material and Methods: In this study, ۷۰۳ patients with both benign and malignant tumors were selected from the Curated Breast Imaging Subset of the Digital Database for Screening Mammography (CBIS-DDSM) database. The embedded method was employed to select the radiomic features of the image and uncover the hidden patterns of data through the Apriori algorithm. Results: The association rules were generated from separated rules for benign and malignancy classes. The important features of the benign class include mass margins, horizontal long-run emphasis, ۱۳۵drfraction, WavEnHLs۳, vertical short-run emphasis, Teta۱, ۴۵dgr run-length with no uniformity, Teta۲, and differential entropy۲. However, the important features of the malignant class include assessment, correlation۴, Teta۱, WavEnLHs۳, contrast۵, vertical short-run emphasis, and differential entropy۲. Conclusion: It can be concluded that the proposed method has been successful in determining specific features for tumor prediction.

Breast Cancer, Radiomics, Data mining, Mammography