Determination of Lithium (I) in Pharmaceutical Products and Biological Samples by a Simple Potentiometric Sensor Based on a Recently Synthesized Chromene Derivative as the Ionophore

سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 38

فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_ANALCH-11-2_004

تاریخ نمایه سازی: 30 اردیبهشت 1403

چکیده مقاله:

In this research, a coated graphite polyvinyl chloride (PVC) membrane electrode was fabricated for the potentiometric determination of lithium based on ۱۳-(۳-nitrophenyl)-۱۲H,۱۴H-benzo[g]chromeno[۲,۳-b]chromene-۷,۱۲,۱۴(۱۳H)-trione (L) as the ionophore. The best Nernstian response was observed from the membrane composition of ۳۱% PVC, ۷% L, ۲% NaTPB, and ۶۰% dioctyl phthalate (DOP) as the plasticizer. The designed sensor showed a wide linearity over the concentration range of ۱×۱۰-۸-۱×۱۰-۳ mol L-۱ with the slope of ۶۰.۲±۰.۳ mV decade-۱, and the limit of detection (LOD) of ۷.۵×۱۰-۹ mol L-۱. The selectivity of the designed sensor was investigated by matched potential method and no serious interference was observed. The response time and life span of the electrode were ۵s and ۱۶ weeks, respectively. The potential response of the electrode was independent of solution pH in the pH range of ۳.۰-۱۲.۰. The influence of the presence of organic solvents on the potential response of the electrode was also scrutinized, and the results showed that the designed sensor keeps its Nernstian behavior in solutions with ۲۰% non-aqueous content. At the end, the electrode was successfully applied to determine lithium carbonate in tablet, urine and serum samples with the recovery% values of ۹۶.۰ to ۱۰۶.۳۳ and RSD% ۱.۹۹-۴.۴۵.

نویسندگان

Parya Khalatbarimohseni

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Mohammad Jalali Sarvestani

Department of Chemistry, faculty of Pharmaceutical chemistry, Tehran Medical sciences, Islamic Azad university, Tehran, Iran

Shahin Ahmadi

Department of Chemistry, faculty of Pharmaceutical chemistry, Tehran Medical sciences, Islamic Azad university, Tehran, Iran

Mohammad Mahboubi-Rabbani

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran