Investigation the effect of a herbal composition based on blackseed on patients with primary hypothyroidism: A randomized controlled trial
- سال انتشار: 1403
- محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 14، شماره: 3
- کد COI اختصاصی: JR_AJP-14-3_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 29
نویسندگان
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective: Hypothyroidism is characterized by insufficient production of thyroxine by the thyroid gland. Levothyroxine may not fully alleviate patients' symptoms. This study aimed to assess the impact of a herbal product on weight, body mass index (BMI), thyroid hormones, lipid profile, fasting blood sugar (FBS), depression, and quality-of-life scores in patients.Materials and Methods: ۷۲ patients with primary hypothyroidism, aged between ۲۰ and ۶۵ years old, participated in the trial and they were randomly allocated into two groups. The intervention group received the herbal powder containing Trachyspermum ammi L., Nigella sativa L., and Citrus aurantifolia L. while the control group received Avicel for ۸ weeks.Results: Treatment with the herbal product resulted in statistically significant reductions in anthropometric variables such as BMI (p=۰.۰۳), hip circumference (HC) (p=۰.۰۰۸), waist circumference (WC) (p< ۰.۰۰۱), and waist-to-hip circumference ratio (WHR) (p=۰.۰۰۳) in the intervention group in comparison between intervention and control groups. However, the decrease in weight was not statistically significant (p=۰.۰۸) in the intervention group compared the control group. In comparison between two groups, the depression score exhibited a statistically significant decrease in the intervention (p=۰.۰۰۱) and control groups (p=۰.۰۱), while there was a statistically significant increase in the quality-of-life score only in the intervention group (p< ۰.۰۰۱) in comparison between intervention and control groups.Conclusion: The results indicate the potential beneficial effects of the herbal product on anthropometric variables in patients. Furthermore, the intervention yielded significant improvements in depression symptoms and quality-of-life scores among the patients.کلیدواژه ها
primary hypothyroidism, Persian Medicine, Traditional, Trachyspermum ammi L, Nigella sativa L, Citrus aurantifolia Lاطلاعات بیشتر در مورد COI
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