Adverse Pregnancy Outcomes and Rheumatoid Arthritis: a Retrospective Matched Cohort Study

  • سال انتشار: 1402
  • محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 31، شماره: 149
  • کد COI اختصاصی: JR_ZUMS-31-149_005
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 37
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نویسندگان

Alireza Sadeghi

Dept. of Internal Medicine, School of Medicine, Vali-e-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

Mina Rostami

Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Nazila Nasiri

Dept. of Internal Medicine, School of Medicine, Vali-e-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

Robabeh Hatami

Dept. of Obstetrics and Gynecology, School of Medicine, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

Arezoo Karimi Moghaddam

Dept. of Ophthalmology, School of Medicine, Vali-E-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

Zhaleh Karimi Moghaddam

Dept. of Radiation Oncology, School of Medicine, Vali-e-asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Alireza Zeraatchi

Dept. of Emergency Medicine, School of Medicine, Valiasr-e-Asr Hospital, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran

چکیده

Background and Objective: Rheumatoid Arthritis (RA) is an autoimmune-driven chronic systemic inflammatory disease. It could result in miscarriage, pre-eclampsia, and preterm labor, among other unfavorable pregnancy outcomes. Thus, this study was conducted to investigate the adverse pregnancy outcomes in pregnant women with RA. Materials and Methods: Two cohorts of pregnant women with and without RA referred to the Ayatollah Mousavi Hospital's Gynecology and Obstetrics Clinic in Zanjan, Iran, during ۲۰۱۹-۲۰۲۰ were enrolled in a retrospective matched cohort study. Using their medical records, each participant completed a checklist of study variables. We used binary Logistic regression, chi-square test, Analysis of Variance, and independent samples t-test to analyze data using SPSS v.۲۳. Results: The study included ۲۸۰ pregnant women. The mean age of the RA and control group (pregnant women without RA) was ۳۲.۴ ± ۶.۶ and ۲۹.۵ ± ۶.۷ years, respectively. The most prevalent adverse outcome was spontaneous abortion (۵۴, ۱۹.۲۸%), which was significantly higher in the RA group (۲۵% vs. ۱۳.۶%, P= ۰.۰۱۵). Cesarean section (۲۴.۳% vs. ۱۰.۷%, P= ۰.۰۰۳) and low birth weight (LBW) were both significantly higher in the RA group (۱۵% vs. ۵%, P= ۰.۰۰۵). RA increased the probability of spontaneous abortion, cesarean section, and LBW by more than ۱.۳ (odds ratio, ۱.۳۸; ۹۵% CI, ۰.۴۵-۵.۴۶; P= ۰.۰۱۷), ۲.۲ (odds ratio, ۲.۲۴; ۹۵% CI, ۱.۲۹-۶.۵۴; P =۰.۰۰۴), and ۲.۶ (odds ratio, ۲.۶۷; ۹۵% CI, ۱.۸۶-۷.۰۵; P= ۰.۰۰۸) times, respectively. Conclusion: Pregnant women with RA are more likely to experience spontaneous abortion, cesarean section, and having LBW infants comparing to pregnant women without RA.

کلیدواژه ها

Rheumatoid Arthritis, Pregnancy, Cesarean Section, Spontaneous Abortion, Low Birth Weight

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