The Effect of Eight Weeks of Combined High Intensity Interval Training on Intrahepatic PGC-۱α and PEPCK Protein in Male Rats with Non-Alcoholic Steatohepatitis
- سال انتشار: 1403
- محل انتشار: فصلنامه تغذیه، روزه داری و سلامت، دوره: 12، شماره: 2
- کد COI اختصاصی: JR_JNFH-12-2_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 53
نویسندگان
MA Student of Sports Nutrition, Zand Institution of Higher Education, Shiraz, Iran.
Assistant Professor of Sports Physiology, Department of Sports Sciences, Zand Institution of Higher Education, Shiraz, Iran.
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
PhD Student of Exercise Physiology, Faculty of Educational Sciences and Psychology, Department of Sports Sciences, Shiraz University, Shiraz, Iran.
چکیده
Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the non-communicable metabolic diseases with high prevalence worldwide. Therefore, treatment strategies for this disease are very important. This research aimed to examine the effect of eight weeks of combined high-intensity interval training on intrahepatic PGC-۱α and PEPCK protein in male rats with non-alcoholic steatohepatitis. Methods: Forty rats aged ۶ to ۸ weeks were divided into two groups: healthy (n=۲۰) and high-fat diet (HFD) (n=۲۰). After eight weeks and assurance of disease induction, the HFD group was randomly divided into two groups: control-patient (n=۹) and training-patient (n=۹). The healthy group was divided into two groups: control-healthy (n=۹) and training-healthy (n=۹). Rats in the training group performed HIIT in both aquatic and land environments (Saturdays and Wednesdays in aquatic environment and Mondays on a treadmill). One-way ANOVA and Bonferroni's post hoc test (P< ۰.۰۵) were run to determine the difference between groups. Results: The findings showed that intrahepatic PGC-۱α protein levels were associated with a significant increase in the healthy control group compared to the patient control (P=۰.۰۴); also, intrahepatic PEPCK protein levels were associated with a significant increase in the control-healthy group compared to the control-patient (P=۰.۰۱) group, a significant increase in the training-healthy group compared to the control-patient (P=۰.۰۰۲) and training-patient (P=۰.۰۳) groups and a significant increase in the training-patient group compared to the control-patient (P=۰.۰۳) group. Conclusion: It can be suggested that combined high intensity interval training can be effective in regulating the PGC-۱α/PEPCK mechanism, which is a potential mechanism in the regulation of glucose and lipid metabolism in the liver. However, further research is needed in this regard to obtain conclusive results.کلیدواژه ها
Peroxisome Proliferator-activated Receptor-γ Coactivator ۱-α (PGC۱α), Phosphoenolpyruvate Carboxykinase (PEPCK), Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), High Intensity Interval Training (HIIT)اطلاعات بیشتر در مورد COI
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