Alpha-pinene alleviates CCl۴-induced renal and testicular injury in rats by targeting oxidative stress, inflammation, and apoptosis
- سال انتشار: 1403
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 27، شماره: 6
- کد COI اختصاصی: JR_IJBMS-27-6_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 174
نویسندگان
Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Department of Biology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Nanobiotechnology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran
چکیده
Objective(s): Renal and testicular disorders are primarily associated with oxidative damage and inflammation. Here, alpha-pinene (a type of monoterpene) was investigated for its effect on oxidative/nitrosative stress and the expression of inflammatory and apoptotic factors in the kidneys and testes of rats treated with CCl۴.Materials and Methods: CCl۴ was injected intraperitoneally (IP) at a dose of ۲ ml/kg (twice a week for six weeks). Alpha-pinene (۵۰ mg/kg/day, IP) was also treated during the same period. Results: CCl۴ increased the level of malondialdehyde (P< ۰.۰۱ in the kidney and P< ۰.۰۰۱ in the testis) and nitric oxide (P< ۰.۰۰۱ in the kidney and P< ۰.۰۱ in the testis) and decreased the levels of glutathione (P< ۰.۰۵) in the kidneys and testicles of rats. CCl۴ also reduced the catalase enzyme activity in the kidneys (P< ۰.۰۵) but did not affect its activity in the testis. In addition, CCl۴ enhanced the mRNA expression of TNF-α (P< ۰.۰۱), nuclear factor-κB (P< ۰.۰۵), and Bax (P< ۰.۰۵ in the kidney and P< ۰.۰۱ in the testis) and decreased the expression of Bcl-۲ (P< ۰.۰۵) in both organs. Alpha-pinene prevented all the mentioned changes, but it did not influence the expression of Bcl-۲ in the kidneys of rats receiving CCl۴. Conclusion: Alpha-pinene may have the potential to prevent renal and testicular diseases by strengthening the antioxidant system in the kidneys and testis, and inhibiting oxidative/nitrosative stress, inflammation, and apoptosis caused by CCl۴.کلیدواژه ها
Alpha-pinene, bcl-۲-Associated X Protein, Inflammation, Kidney, Oxidative stress, Testisاطلاعات بیشتر در مورد COI
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