Protective effects of silymarin-loaded chitosan nanoparticles in the diet-induced hyperlipidemia rat model
- سال انتشار: 1403
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 27، شماره: 6
- کد COI اختصاصی: JR_IJBMS-27-6_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 181
نویسندگان
Department of Veterinary Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Veterinary Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Veterinary Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Veterinary Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
Objective(s): Obesity is a metabolic syndrome that leads to many chronic diseases worldwide. In this study, we investigate the antihyperlipidemic activities of chitosan nanoparticles (CH NPs) on silymarin (SIL) as a carrier in the drug delivery system that can improve some biochemical parameters and hormones in the model of hyperlipidemic rats receiving a high-fat diet (HFD). Materials and Methods: Physicochemical characterization of silymarin-loaded chitosannanoparticles (CH-SIL NPs) was done by Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), and drug loading efficiency (LE). Diet-induced hyperlipidemic rats were treated with SIL (۱۵ mg/kg/day) and CH-SIL NPs(۱۵ mg/kg/day) for twelve weeks orally daily. The body weight loss (BW), food consumption, serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), levels of fasting blood glucose (FBG) in serum, serum insulin, cortisol, testosterone, and brain neuropeptide Y (NPY), Y۱ and Y۵ receptor mRNA expression were analyzed. Results: A significant reduction in BW and food consumption from ۴۱۷ ± ۱۶ g and ۳۳ ± ۱.۰۳ in group HFD to ۳۳۸ ± ۱۰ g and ۱۷.۳۳ ± ۱.۰۲ in group CHS+HFD was observed, respectively. This data revealed that CH-SIL NPs improved hyperlipidemia, hyperinsulinemia, and hyperglycemia, reduced serum cortisol, and down-regulated NPY and Y۱R with a significant increase in HDL and testosterone hormones compared to the control group. Conclusion: The developed Sil-loaded CH NPs were good agents for improving efficacy. It is the first report of the proposed weight loss mechanism of SIL CH NPs, thereby providing information about the anti-hyperlipidemic and antihyperglycemic effects of silymarin-loaded chitosan nanoparticles, a natural food with proper effects against metabolic disorders in case of hyperlipidemia that may lead to obesity and up-regulation of brain NPY.کلیدواژه ها
Antiobesity, Body mass index, Chitosan, Dyslipidemia, High cholesterol diet, HOMA-IR, Silymarinاطلاعات بیشتر در مورد COI
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