Iron serum level and TIBC in porkinson disease
عنوان مقاله: Iron serum level and TIBC in porkinson disease
شناسه ملی مقاله: JR_JKMU-8-1_005
منتشر شده در در سال 1380
شناسه ملی مقاله: JR_JKMU-8-1_005
منتشر شده در در سال 1380
مشخصات نویسندگان مقاله:
B Sedighi - Assistant professor
G Mansoori - .
خلاصه مقاله:
B Sedighi - Assistant professor
G Mansoori - .
Parkinson disease is one of the neurodegenetive disease with a prevalence of about ۱% in people older than ۶۵.from a pathological point of view,degeneration of neuromelanin cells in pars compacta of substantia nigra has been established.the reason of degeneration is unknouwn.increase in iron concentration in substantia of parkinson,s patients has been established.the increase of iron in this part of brain is due to the altered systemic iron methablism in these patients.in this study the serum levels of iron and TIBC in ۳۴ patients and ۱۰۲ matched healthy persons were measured.normality of HB,Hct,MCV,MCH were considered as inclusion criterion in both groups.two sample t-test indicated that iron serum level and TIBC in parkinson patients were significantly lower than the controls(p<۰.۰۰۰۱).Hct and Hb levels were lower whereas MCV and MCH levels were higher in patients group.a significant difference was observed between the two groups for iron serum level and TIBC.there was no relationship between age,sex,the disease duration and its severity with iron serum level and TIBC,due to iron sedimentation in substantia nigro in patients,this study may prove the role of iron in the pathogenesis or the defect in systematic iron metabolism,in this disease.
کلمات کلیدی: Parkinson, s disease, Serum iron, serum TIBC, Kerman
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1934064/