Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid Hypertrophy
- سال انتشار: 1403
- محل انتشار: مجله علمی گوش و حلق و بینی ایران، دوره: 36، شماره: 2
- کد COI اختصاصی: JR_IJOTO-36-2_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 148
نویسندگان
Division of Infectious Diseases, Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Pediatric Gastroenterology and Hepatology Research Center, Division of Gastroenterology, Department of Pediatric, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Division of Gastroenterology, Department of Pediatrics, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Division of Allergy and Clinical Immunology, Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Division of Allergy and Clinical Immunology, Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.
چکیده
Introduction: Adenoid hypertrophy is a common childhood disease; its standard treatment is adenoidectomy. The desire for medical management is increasing due to fewer complications and more convenience. The present study investigated the effect of adding oral montelukast to mometasone nasal spray in treating adenoid hypertrophy. Materials and Methods: This was a randomized, double-blind, placebo-controlled study conducted at a referral teaching hospital (Tehran, Iran) from September ۲۰۲۰ to September ۲۰۲۱. Children aged ۲ to ۱۴ years with clinical and radiological findings of adenoid hypertrophy were enrolled. Patients were randomly divided into two groups: mometasone nasal spray with oral montelukast (case group) or mometasone with placebo (control group). Then, the clinical scores were compared before and two months after the intervention. Results: Ninety-six patients completed the study [۶۲.۵% male (n=۶۰)]. Of these, ۵۱ were in the case and ۴۵ in the control group. The clinical score in each group decreased significantly after the intervention (P< ۰.۰۰۱), but the decrease in clinical score in the case group was not significantly different from the control (p=۰.۵۷۶). Conclusion: The results showed that the combination therapy with mometasone and montelukast has the same efficacy as mometasone and placebo in treating adenoid hypertrophy. Adding montelukast to mometasone has no additional effect.کلیدواژه ها
Adenoid, Children, Mometasone furoate, Montelukastاطلاعات بیشتر در مورد COI
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