Detection of Human Papillomavirus in Osophageal Squamous Cell Carcinoma samples in Mazandaran Province, Iran
- سال انتشار: 1396
- محل انتشار: مجله بین المللی میکروبیولوژی مولکولی و بالینی، دوره: 7، شماره: 1
- کد COI اختصاصی: JR_IJMCM-7-1_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 38
نویسندگان
Department of Medical Virology, Golestan University of Medical Sciences, Gorgan, Iran
infectious diseases research center, Golestan University of Medical Sciences, Gorgan, Iran
Department of Medical Virology, Golestan University of Medical Sciences, Gorgan, Iran
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Infectious Diseases & Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran
چکیده
We examined ۱۷۰ formalin-fixed paraffin-embedded samples from esophageal squamous cell carcinoma patients. All subjects live in Mazandaran province, a region with high incidence rate of esophageal cancer and have become known as the “Asian Esophageal Cancer Belt”. Samples were tested for HPV-DNA by MY۰۹/۱۱ and Gp۵+/۶+ general primers using nested PCR. Of the ۱۷۰ ESCC samples, ۸۶ (۵۰.۶%) were male and ۸۴ (۴۹.۴%) were female. The mean age of the subjects was ۶۶.۵±۱۱.۱ and ranged from ۳۵ to ۹۱ years. Totally, HPV-DNA was detected in ۶۲ (۳۶.۵%) of the esophageal squamous cell carcinoma samples by HPV L۱ consensus primers. Considering the location of esophagus specimens, of ۶۲ positive samples, ۱۶ (۲۵.۸%) samples were in the upper third, ۲۸ (۴۵.۲%) in the middle third, and ۱۸(۲۹.۰%) in the lower third. The current study showed a relatively substantial prevalence of HPV infection in esophageal squamous cell carcinoma samples in Mazandaran province.کلیدواژه ها
HPV, Nested PCR, Osophageal Cancer, Mazandaran, Iranاطلاعات بیشتر در مورد COI
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