The role of Herpes Simplex Viruses in triggering type ۲ diabetes
عنوان مقاله: The role of Herpes Simplex Viruses in triggering type ۲ diabetes
شناسه ملی مقاله: JR_IJMCM-12-2_007
منتشر شده در در سال 1401
شناسه ملی مقاله: JR_IJMCM-12-2_007
منتشر شده در در سال 1401
مشخصات نویسندگان مقاله:
Sanaz Vahabi - Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
Atousa Ferdousi - Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
Mohammad Hassan Shahhosseini - Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
خلاصه مقاله:
Sanaz Vahabi - Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
Atousa Ferdousi - Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
Mohammad Hassan Shahhosseini - Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
Recently, some common viruses, like Herpes Simplex Virus (HSV), have been proposed as a risk factor to develop type ۲ diabetes. However, still there is not enough literature to determine its importance as a triggering or risk factor. This case-control study is designed to evaluate the Attendance rate of the HSV genome in serum samples of diabetic patients. The study and control groups included ۵۰ serum samples of diabetic type ۲ and ۵۰ non-diabetic respectively. The detecting PCR test for HSV genome types ۱ and ۲ with common DNA polymerase gene region, as the target gene, was optimized. Demographic parameters like Sex, age, and A۱C were recorded too. Amplicon size was ۴۵۴ bp. The specificity and sensitivity of the PCR reaction were۱۰۰% and ۵۰ Copy/reaction respectively. The analysis results showed that neither the genome of HSV-۱ nor ۲ was found in those ۱۰۰ serum samples. In addition, there was no relation between sex or A۱C level and HSV genome presence. But it seems the relatively young age of this group is effective for obtaining these negative results. The small size of this population with negative PCR results, clearly shows that HSV infection cannot be a first-order risk factor, but due to time-consuming mechanisms of probable effects, this may affect elderly populations, as obtained results of some studies. Therefore to prevent or manage type ۲ diabetes, still should be more focused on the conventional risk factors such as obesity and malnutrition.
کلمات کلیدی: Herpes Simplex Viruses, Diabetes, PCR, Infectious diseases, metabolic disorders
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1932700/