Antidepressant Effect of Sour Orange flowers Extract on Lipopolysaccharide-induced Depressive-like Behaviors in Rat
- سال انتشار: 1384
- محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 12، شماره: 2
- کد COI اختصاصی: JR_JKMU-12-2_004
- زبان مقاله: فارسی
- تعداد مشاهده: 34
نویسندگان
Immunologist, Neuroscience Research Center, Kerman University of Medical Sciences and Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Instructor, Physiology and Pharmacology Department, Kerman University of Medical Sciences, Kerman, Iran
Associate Professor of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Technologist, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
Instructor, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
چکیده
Introduction: Based on the documents in traditional medicine regarding the therapeutic effect of Sour orange flowers (Citrus aurantium L.) on the nervous system disorders, this experimental study was conducted to evaluate the pretreatment of Sour orange flowers extract in preventing or reducing depressive-like behaviors induced by systemic injection of lipopolysaccharide (LPS) in rats. Method: To perform this study, percolated extract of sour orange flowers was used. Each experimental group of animals was pretreated with the extract along with drinking water before the injection of LPS. The depressive-like behaviors induced by the injection of LPS consisted of the reduction in the preference for sucrose solutions, food consumption, body weight and inability to pleasure. Results: The LPS-injected rats that were chronically pretreated with the extract improved sucrose preference compared with control group, however this was not significant. Food consumption in extract-pretreated group was significantly increased on day ۲ and ۳ after the injection of LPS compared with control group (P< ۰.۰۵). The effect of extract and LPS on social interaction (consisting of body sniffing and grooming) showed that in extract pretreated rats, the time spent for social interaction was equal to that before the injection (baseline). However in control group there was a significant reduction in the time spent for social interaction compared to the baseline. Conclusion: Considering the effect of LPS in reduction of neurotransmitters such as serotonin and norepinephrine, the attenuation of Sour orange flowers extract on the effect of LPS might be the result of the effect of extract in increasing the level of these neurotransmitter at their site of the activity. To confirm this, more studies to evaluate the pharmacological effect of extract are required.کلیدواژه ها
Sour orange flowers, Depressive-like behavior, Lipopolysaccharideاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.