Aspirin administration from early pregnancy versus initiation after ۱۱ weeks of gestation for prevention of pre-eclampsia in high-risk pregnant women: Study protocol for randomized controlled trial
- سال انتشار: 1402
- محل انتشار: مجله طب تولید مثل ایران، دوره: 22، شماره: 1
- کد COI اختصاصی: JR_IJRM-22-1_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 57
نویسندگان
Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Department of Perinatology, Vali-E-Asr Hospital, Imam Khomeini Hospital Complex, Tehran, Iran.
Iran University of Medical Sciences, Tehran, Iran.
Asklepios Psychiatry Lower Saxony GmbH, Asklepios Specialist Clinic, Gottingen, Germany.
Hannover Medical School, Clinic for Urology, Hannover, Germany.
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medicine Sciences, Isfahan, Iran.
Vali-E-Asr Hospital, Imam Khomeini Hospital Complex, Iran.
چکیده
Background: Pre-eclampsia (PE) is a multiorgan disorder that affects ۲-۵% of all pregnant women. Present recommendations for when to start aspirin in high-risk women are after ۱۱ wk of gestation. Objective: We present a protocol to investigate the effectiveness of aspirin use from early pregnancy, which is a randomized controlled trial to assess whether prescribed low-dose aspirin from early pregnancy reduces the prevalence of early and late-onset PE. Additionally, to compare the effectiveness of aspirin administration before and after ۱۱ wk in reducing the occurrence of PE? Materials and Methods: All pregnancies at risk of PE, according to demographic and midwifery history, who are referred to the Maternal-Fetal Clinic of Tehran University hospital, Tehran, Iran were invited to take part in the trial. The outcomes of pregnancy and newborns will be gathered and analyzed. The first registration for the pilot study was in January ۲۰۲۳, and the participants were recognized as high-risk for PE. In addition, enrollment in the main study will begin as of October ۲۰۲۳.کلیدواژه ها
Pre-eclampsia, Aspirin, Color doppler ultrasonography, Pregnancy, First trimester, Pregnancy-associated plasma protein-A., پره اکلامپسی, آسپرین, سونوگرافی داپلر رنگی, بارداری, سه ماهه اول, پروتئین پلاسمای مرتبط با بارداری-A.اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.