Maryam Nazari - Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Farzad Khademi - Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

BACKGROUND AND OBJECTIVESStreptococcus (S.) agalactiae colonizes in the female genitourinary and lower gastrointestinaltracts and is responsible for a wide range of infections in newborns, pregnant women andnon-pregnant adults. Therefore, antibiotic prophylaxis and infection treatment against S.agalactiae is important. The aim of this study was to determine the prevalence of S. agalactiaeantibiotic resistance in Iranian patients, especially among pregnant women.MATERIALS AND METHODSA systematic literature search was conducted in PubMed, Scopus, Google Scholar and theScientific Information Database (SID) databases by using related keywords and without anytime limitation.RESULTS AND DISCUSSIONA total of ۲۶ studies reporting the prevalence of S. agalactiae antibiotic resistance in Iran metour predefined inclusion and exclusion criteria and were included in the meta-analysis. Highrates of S. agalactiae antibiotic resistance in pregnant women were found against tetracycline(۹۶.۲%), trimethoprim-sulfamethoxazole (۸۴.۷%), cefotaxime (۴۱.۳%), clindamycin (۲۶.۸%)and erythromycin (۲۱%). Additionally, resistance to penicillin (۴.۲%), ampicillin (۲.۷%),cefazolin (۷.۶%), vancomycin (۲.۴%), ceftriaxone (۱۲.۵%), ciprofloxacin (۱۳.۶%) andnitrofurantoin (۰%) was low.CONCLUSIONOur results revealed that penicillin and ampicillin among penicillin-tolerant Iranian pregnantwomen, and vancomycin and cefazolin among penicillin-allergic women are still drugs ofchoice in intrapartum prophylaxis for preventing S. agalactiae vertical transmission andearly-onset neonatal disease.

Antibiotic resistance, Streptococcus agalactiae, Iran