A Systematic Review Study on the Role of Long Non-coding RNAs (lncRNAs) in Mycobacterium tuberculosis
- سال انتشار: 1402
- محل انتشار: فصلنامه میکروب شناسی پزشکی ایران، دوره: 17، شماره: 5
- کد COI اختصاصی: JR_IJMM-17-5_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 220
نویسندگان
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Department of Microbiology, Ardabil University of Medical Sciences, Ardabil, Iran
Department of Microbiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of Microbiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Mycobacterium tuberculosis is the bacterium that causes tuberculosis. In this bacteria, long non-coding RNAs (lncRNA) can positively and negatively alter the expression of various genes through various mechanisms, such as activating transcription factors or binding to DNA targets of the chromatin complex. The current study's purpose was to review the lncRNAs in M. tuberculosis. The search was done with the keyword including lncRNAs, lncRNA, Long ncRNA, LincRNAs, Long ncRNA, long noncoding RNA, TB, Pulmonary Tuberculosis, Pulmonary TB, Mycobacterium tuberculosis in Pub Med, Web of Science Direct, Scopus, Scientific Information Databases, and Google scholar between ۲۰۰۰ and ۲۰۲۰. A total of ۱۲۴ articles were found in PubMed,Science Direct, Scopus, Ovid, Cochrane, and Google Scholar, of which ۲۰ papers were selected from the databases. In revising the title and abstract, ۸۴ articles were excluded from our study. Finally, ۱۹ articles were included in our study, which included ۴۴۴۴ patients with tuberculosis. All studies were performed in China using the qRT-PCR method. The present study's results showed an acceptable association between lncRNA and SNP with tuberculosis and M. tuberculosis. Also, these regulatory factors play an essential role as diagnostic biomarkers and the development of new therapies.کلیدواژه ها
long non-coding RNAs, systematic review, biomarker, TB, lincRNAs, RNA های طولانی غیرکدکننده, بررسی سیستماتیک, بیومارکر, سل, lncRNAsاطلاعات بیشتر در مورد COI
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