Exploring Biomarker Profiles in Breast Carcinoma with Nervous System Metastasis

  • سال انتشار: 1403
  • محل انتشار: مجله اوراسیا تحقیقات در شیمی، پزشکی و نفت، دوره: 3، شماره: 1
  • کد COI اختصاصی: JR_EJCMPR-3-1_018
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 57
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نویسندگان

Reza Eghdam Zamiri

Associate Professor of Radiology, Department of Radiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Saeid Charsouei

Associate Professor of Neurology, Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

چکیده

Introduction: The exploration of biomarker profiles in breast carcinoma with nervous system metastasis represents a critical frontier in cancer research. This endeavor holds the potential to revolutionize diagnostic accuracy, prognostic precision, and therapeutic strategies for patients grappling with this aggressive form of cancer. As research progresses, the integration of biomarker information into clinical practice may usher in a new era of personalized medicine, offering hope for improved outcomes and a better quality of life for those affected by breast carcinoma with nervous system metastasisMaterial and Methods: This retrospective study analyzed ۱۵۰ breast carcinoma patients with nervous system metastasis. Clinical data were sourced from records, and tissue samples underwent immunohistochemistry and gene expression profiling. Statistical analyses, including survival curves, explored biomarker associations. A ۷۵-patient validation cohort supported findings.Results: Microarray analysis of gene expression profiles identified distinct molecular signatures associated with nervous system metastasis. Pathway enrichment analysis revealed upregulation of genes associated with cell migration, angiogenesis, and neuroinflammation.Conclusion: Our exploration of biomarker profiles in breast carcinoma patients with nervous system metastasis has provided a nuanced perspective on the molecular intricacies of this formidable disease. The integration of clinical, pathological, and molecular data has facilitated a comprehensive understanding of the heterogeneity inherent in nervous system metastasis.

کلیدواژه ها

Biomarker Profiles, Breast carcinoma, nervous system, Metastasis

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