Comparison of Immune Responses following Intradermal and Intramuscular Rabies Vaccination Methods
- سال انتشار: 1397
- محل انتشار: مجله میکروبیولوژی پزشکی و بیماریهای عفونی، دوره: 6، شماره: 4
- کد COI اختصاصی: JR_JMMI-6-4_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 49
نویسندگان
Department of Virology, Pasteur Institute of Iran, Tehran, Iran
Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran
Department of Virology, Pasteur Institute of Iran, Tehran, Iran
Department of Virology, Pasteur Institute of Iran, Tehran, Iran
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Zoonosis Control Department, Center for Communicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran
Department of Zoonosis Control, Center for Communicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran
Department of Virology, Pasteur Institute of Iran, Tehran, Iran
چکیده
Rabies is a zoonotic viral disease. The causative agent is a negative-sense RNA genome virus of the genus Lyssavirus (Family: Rhabdoviridae). The disease, commonly transmitted by rabid dogs, is the cause of mortality of over ۵۹۰۰۰ humans worldwide annually. This disease can be prevented before the development of symptoms through proper vaccination even after exposure. Hence, improvement of the vaccination schedule in the countries where rabies is endemic is essential. In addition to the type of vaccine, injection routes also contribute to enhanced immune responses and increased potency of the vaccines. The vaccines approved by the World Health Organization (WHO) include cell culture and embryonated egg-based rabies vaccines (CCEEVs). In order to develop a vaccine against rabies, it is necessary to use an appropriate delivery system to promote a proper antigen-specific immune response. Different routes of injection such as intradermal (ID), intramuscular (IM) or subcutaneous (SC) are practiced, with controversies over their suitability. In this article, we discuss the immunological aspects of rabies vaccination by comparing ID and IM delivery systems.کلیدواژه ها
Rabies Vaccine, Rabies, Immunization Schedule, Vaccination, Lyssavirusاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.