The Association of Non-polio Enteroviruses with Aseptic Meningitis in Children in Iran
- سال انتشار: 1393
- محل انتشار: مجله میکروبیولوژی پزشکی و بیماریهای عفونی، دوره: 2، شماره: 2
- کد COI اختصاصی: JR_JMMI-2-2_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 86
نویسندگان
Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran
Department of Microbiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Introduction : Viral meningitis is an inflammation of the leptomeninges as a manifestation of central nervous system (CNS) infection, and more than ۸۵% of viral meningitis cases are caused by non-polio enteroviruses. Molecular methods such as polymerase chain reaction (PCR) are increasingly used to detect and type non-polio enteroviruses. Here, we describe the impact of these viruses on aseptic meningitis in young children in Iran. Methods: Cerebrospinal fluids were collected from ۳۶۶ children under ۸ years old with primary clinical diagnosis of aseptic meningitis. Real-Time RT-PCR and PCR were performed using specific primers for each human enterovirus (HEV), human parechovirus (HPeV), and enterovirus ۷۱ (EV۷۱). Results: Positive results were obtained for HEV, HPeV, and EV۷۱ in ۱۱۸ (۳۲.۲%), ۱۵۴ (۴۲%), and ۹۴ (۲۵.۷%) patients, respectively. HPeV detection rate was higher in both male and female patients with no statistically significant difference. Conclusion: Using molecular methods, such as PCR as routine laboratory diagnostic tests for HEVs will result in better understanding of disease burden of these viruses, especially in central nervous system involvements, and will consequently reduce hospitalization and use of antibiotic, which often lead to other complications. J Med Microbiol Infec Dis, ۲۰۱۴, ۲ (۲): ۵ pages.کلیدواژه ها
Non-polio enteroviruses, Human enteroviruses, Parechoviruses, Enterovirus ۷۱, aseptic meningitis.اطلاعات بیشتر در مورد COI
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