Prevalence and Risk Factors of Pulmonary Fungal Pathogens among Symptomatic Patients with or without Tuberculosis at Gombe, Nigeria
- سال انتشار: 1399
- محل انتشار: مجله میکروبیولوژی پزشکی و بیماریهای عفونی، دوره: 8، شماره: 3
- کد COI اختصاصی: JR_JMMI-8-3_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 59
نویسندگان
Department of Biological Sciences, Abubakar Tafawa Balewa University, Bauchi, Nigeria
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria
Nigeria Field Epidemiology and Laboratory Training Program, African Field Epidemiology Network, Abuja, Nigeria
WHO National Polio Laboratory, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria
Department of Medical Microbiology, Federal School of Medical Laboratory Science, Jos, Nigeria
Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja Nigeria
Department of Medical Microbiology and Parasitology, University of Ilorin Teaching Hospital, Ilorin, Nigeria
Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja Nigeria
چکیده
Introduction: Pulmonary fungal infections are a significant etiology of morbidity among immunocompromised and immunosuppressed patients. This study aimed to determine the prevalence of fungal pathogens and associated risk factors among pulmonary tuberculosis (PTB) and non-PTB patients attending Federal Teaching Hospital, Gombe, Nigeria. Methods: Three consecutive early morning sputum samples were collected from ۴۳ PTB patients and ۱۷۳ non-PTB persons and then examined for fungal pathogens using standard mycological stains, microscopy, and biochemical assays. All the participants were screened for HIV by the World Health Organization HIV testing algorithm and M. tuberculosis infection using GeneXpert ® nested PCR equipment. Samples with at least two significant fungal growths were considered positive. Results: Out of ۲۱۶ sputa, ۷۳.۶% showed fungal growth in cultures. One hundred percent and ۶۷% of PTB and non-PTB participants had positive sputa culture, respectively. In PTB patients, Candida albicans (۲۵.۶%) and Aspergillus fumigatus (۲۰.۹%), and in non-PTB individuals A. fumigatus (۵۱.۷%) and A. nigar (۱۷.۲%) were the most prevalent species. Age and residential areas were significantly associated with fungal infection in PTB and non-PTB subjects (p˂۰.۰۵). Cigarette smoking, prolonged antibiotic use, and having domestic pets were significant risk factors for developing pulmonary fungal infections in both groups (p˂۰.۰۵). None of the studied risk factors was significantly associated with pulmonary mycosis among TB patients (p˃۰.۰۵). However, prolonged use of antibiotics was a significant risk factor of pulmonary fungal infection among non-TB patients (p=۰.۰۰۹). Conclusion: Our study showed that PTB was a predisposing factor for fungal infection, especially among individuals with low socioeconomic status.کلیدواژه ها
Pulmonary Symptoms, Risk factors, Fungal Infection, Mycosis, Tuberculosis coinfectionاطلاعات بیشتر در مورد COI
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