Effect of Diesel Oil Vapor Inhalation on Liver Function in Male Rat
- سال انتشار: 1394
- محل انتشار: مجله بین المللی مطالعات سلامت، دوره: 1، شماره: 2
- کد COI اختصاصی: JR_IJHS-1-2_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 29
نویسندگان
۱. Dept. of Microbiology, School of Sciences, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.
۲. Dept. of Biostatistics and Epidemiology, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran.
۳. Dept. of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran.
۴. Dept. of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.
چکیده
Background: Studies show that there is association between air pollution and disturbances on normal function of various systems of body. The main aim of this study was to determine the effects of diesel oil vapor inhalation on serum creatine, alkaline phosphatase, SGOT and SGPT levels as indices of liver function in male rats.Methods: Thirty two rats were randomly divided into ۴ groups: control and three treatment groups that exposed to diesel oil vapor for ۱ hour/day, for ۲ hours/day and for ۳ hours/day. After a period of ۶ weeks, blood samples were collected and investigated. Serum level of alkaline phosphatase, creatine, glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT) were measured by spectrophotometry method. Results: Our findings indicated that there was no significant difference between serum alkaline level of control and experimental rats. Serum creatine level was significantly increased in rats exposed to diesel oil for ۱hour/day, ۲h/day and ۳h/day (P< ۰.۰۰۱, P< ۰.۰۱ and P< ۰.۰۰۱, respectively). Also, SGOT was significantly decreased in rats exposed to diesel oil for ۲h/day and ۳h/day (P< ۰.۰۱ and P< ۰.۰۵, respectively). SGPT was non-significantly decreased in rats exposed to diesel oil vapor compared with control animals. Conclusions: We have shown that exposure to diesel oil vapor can bring about enhanced kinase level, decreased SGPT level indicating the health risk caused by exposure to diesel oil inhalation, in particular, to liver.Background: Studies show that there is association between air pollution and disturbances on normal function of various systems of body. The main aim of this study was to determine the effects of diesel oil vapor inhalation on serum creatine, alkaline phosphatase, SGOT and SGPT levels as indices of liver function in male rats. Methods: Thirty two rats were randomly divided into ۴ groups: control and three treatment groups that exposed to diesel oil vapor for ۱ hour/day, for ۲ hours/day and for ۳ hours/day. After a period of ۶ weeks, blood samples were collected and investigated. Serum level of alkaline phosphatase, creatine, glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT) were measured by spectrophotometry method. Results: Our findings indicated that there was no significant difference between serum alkaline level of control and experimental rats. Serum creatine level was significantly increased in rats exposed to diesel oil for ۱hour/day, ۲h/day and ۳h/day (P< ۰.۰۰۱, P< ۰.۰۱ and P< ۰.۰۰۱, respectively). Also, SGOT was significantly decreased in rats exposed to diesel oil for ۲h/day and ۳h/day (P< ۰.۰۱ and P< ۰.۰۵, respectively). SGPT was non-significantly decreased in rats exposed to diesel oil vapor compared with control animals. Conclusions: We have shown that exposure to diesel oil vapor can bring about enhanced kinase level, decreased SGPT level indicating the health risk caused by exposure to diesel oil inhalation, in particular, to liver.کلیدواژه ها
Diesel oil, CK, Alakaline Phosphatase, SGPT.اطلاعات بیشتر در مورد COI
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