Ehsan Binesh ۱ - ۱. Department of Infectious, Imam Hossain Center for Education, Research and Treatment, Shahroud University of Medical Sciences, Shahroud, Iran.
Mehdi Mirzaii ۲ - ۲. Department of Microbiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Fateme Asadi ۳ - ۳. Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Pouneh Zolfaghari ۴ - ۴. Vice-chancellery of Health, Shahroud University of Medical Sciences, Shahroud, Iran.
Nasim Nikkheslat ۴
Mohammad Bagher Sohrabi ۵ - ۵. School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

Background: Urinary tract infection (UTI) is one of the most common bacterial infections. The most common cause is Escherichia coli. This research is done with the aim at compare effect of ciprofloxacin with nalidixic acid in the infection of different parts of the urinary tract.Methods: In this cross-sectional study, ۱۳۰ patients with symptoms of the urinary tract infection referred to Imam Hossain Hospital of Shahrood were studied. For the all patients, urine samples were collected by standard method and urine analysis and culture was performed. Then, positive culture samples were tested by antibiogram and the resistance rate for the two antibiotics ciprofloxacin and nalidixic acid and MBC and MIC was investigated.Results: Of the ۱۳۰ patients with symptoms of UTI (fever, flank pain or tenderness and dysuria, urgency or frequency (۸۴ patients had positive urine culture. Of all patients with positive urine, ۳۱ cases had symptoms of pyelonephritis, ۲۵ patients had symptoms of cystitis and ۲۸ patients had symptoms of UTI. In antibiogram for positive urine samples, ۲۱ pieces were resistant to ciprofloxacin and ۴۶ pieces were resistant to nalidixic acid which significantly reduced resistance to ciprofloxacin (P=۰.۰۰۵). There was no significant difference between the two antibiotics in place of clinical symptoms and drug resistance. So there was no significant difference between the two MIC and MBC in place of clinical symptoms and drug resistance.Conclusions: This study showed that ciprofloxacin is more effective in controlling infection of different parts of the urinary tract due to less drug resistance.Background: Urinary tract infection (UTI) is one of the most common bacterial infections. The most common cause is Escherichia coli. This research is done with the aim at compare effect of ciprofloxacin with nalidixic acid in the infection of different parts of the urinary tract. Methods: In this cross-sectional study, ۱۳۰ patients with symptoms of the urinary tract infection referred to Imam Hossain Hospital of Shahrood were studied. For the all patients, urine samples were collected by standard method and urine analysis and culture was performed. Then, positive culture samples were tested by antibiogram and the resistance rate for the two antibiotics ciprofloxacin and nalidixic acid and MBC and MIC was investigated. Results: Of the ۱۳۰ patients with symptoms of UTI (fever, flank pain or tenderness and dysuria, urgency or frequency (۸۴ patients had positive urine culture. Of all patients with positive urine, ۳۱ cases had symptoms of pyelonephritis, ۲۵ patients had symptoms of cystitis and ۲۸ patients had symptoms of UTI. In antibiogram for positive urine samples, ۲۱ pieces were resistant to ciprofloxacin and ۴۶ pieces were resistant to nalidixic acid which significantly reduced resistance to ciprofloxacin (P=۰.۰۰۵). There was no significant difference between the two antibiotics in place of clinical symptoms and drug resistance. So there was no significant difference between the two MIC and MBC in place of clinical symptoms and drug resistance. Conclusions: This study showed that ciprofloxacin is more effective in controlling infection of different parts of the urinary tract due to less drug resistance.

Escherichia coli, Ciprofloxacin, Nalidixic acid, Urinary tract infection, Antibiotic resistance