Naser Zangiabadi
Mandana Jafari
Mohammad Shaabani

Introduction: Diabetes is the most common cause of peripheral nerve involvement. Evaluating the effect of antioxidants on diabetic neuropathic pain is important. This study aimed at evaluating the effects of Angipars medicine in the treatment of neuropathic hyperalgesia in single dose streptozotocin-induced diabetic rats. Methods: The study was performed on ۵۰ Spraque dawley rats of ۲۵۰-۳۰۰ grams weight. The rats were divided into four groups of control, sham, Angipars-receiving diabetic, and vehicle-receiving diabetic, with at least ۸ rats in each group. Diabetes was induced by intraperitoneal injection of ۴۵ mg/kg streptozotocin dissolved in a ۰.۰۵ M citrate buffer. After confirming the diabetes, the diabetic rats received (۵, ۱۰, ۲۰ mg/kg, intraperitoneal) Angipars and vehicle for ۲ weeks. At the end of the eighth week, the control and treated rats were examined through the hot plate and tail flick tests. ANOVA was used to evaluate the statistical difference and pvalue<۰.۰۵ was considered as significant. Results: At the end of the eighth week, the response time to thermal hyperalgesia decreased in the vehicle and sham groups compared with the control group. Angipars at doses of ۵ and ۱۰ mg increased the response time to thermal hyperalgesia compared to the vehicle and sham groups in hot plate test. In the tail flick test, ۱۰mg Angipars increased the response time to pain similar to the control group. Conclusion: This study showed that, as an antioxidant, Angipars is capable of reducing neuropathic hyperalgesia in animals with diabetes.

Diabetic Neuropathies, Rats, Pain, Diabetic Neuropathies, Rats, Pain