Serum butyrylcholinesterase activity and phenotype associations with lipid profile during various phases of menstrual cycle in young healthy women with regular menses, a preliminary report
- سال انتشار: 1392
- محل انتشار: مجله بیوشیمی پزشکی، دوره: 1، شماره: 1
- کد COI اختصاصی: JR_MEBIO-1-1_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 77
نویسندگان
چکیده
Objectives: In this study the association of phenotypes and activity of butyrylcholin-esterase (BuChE) with serum level of lipid-lipoprotein and apolipoproteins during var-ious phases of menstrual-cycle was determined. Methods: The study population consisted of ۲۲ healthy women aged ۱۹–۲۵ years with regular menstrual cycles, ۲۶–۳۰ days in length. The serum levels of lipids, apolipoproteins, and BuChE activity were determined during menses (days ۱-۲ after the beginning of menstruations), follicular (days ۷-۸) and luteal (days ۲۱-۲۲) phases of the menstrual cycle. Results: There were significant differences in the level of serum BuChE activity dur-ing three phases of the menstrual cycle (P=۰.۰۴۹). The activity of serum BuChE was the highest during follicular phase (۸۹۰ ± ۲۹۲ IU/L), the modest during the menses phase (۸۳۱ ± ۲۲۲ IU/L) and the lowest during luteal phase (۷۰۷ ±۲۱۱ IU/L). We found a significant positive correlation between BuChE activity with the levels of low density lipoprotein cholesterol (LDL-C, r=۰.۳۴, P=۰.۰۳۸) in the follicular and in the menses phase with LDL-C (r=۰.۴, P =۰.۰۲۵) and triacylglycerol (r=۰.۴۷, P=۰.۰۳۳). In addi-tion, carriers of the non-UU phenotypes (non-wild type low BuChE activity) had signif-icantly lower levels of serum high density lipoprotein cholesterol (HDL-C) and apolipoprotein A۱ (APOA۱) compared to UU phenotype (usual or wild type) during menstrual cycle. Conclusion: Our results demonstrate that serum BuChE activity elevates during menstrual cycle. It is low during luteal phase and reaches to a high level in follicular-phase. The lipid profiles are also affected by BuChE activity throughout the menstru-al-cycle in reproductive aged, regularly cycling and young healthy women.کلیدواژه ها
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